Highly Enantioselective Production of Chiral Secondary Alcohols with Candida zeylanoides as a New Whole Cell Biocatalyst

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dc.authorid37098938400
dc.authorid36815706500
dc.contributor.authorŞahin E.
dc.contributor.authorDertli E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:15Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:15Z
dc.date.issued2017
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols results from the outstanding characteristics of biocatalysts in reaction, economic, and ecological issues. Herein, fifteen yeast strains belonging to three food originated yeast species Candida zeylanoides, Pichia fermentans, and Saccharomyces uvarum were tested for their capability for asymmetric reduction of acetophenone to 1-phenylethanol as biocatalysts. Of these strains, C. zeylanoides P1 showed an effective asymmetric reduction ability. Under optimized conditions, substituted acetophenones were converted to corresponding optically active secondary alcohols in up to 99% enantiomeric excess and at high yields. The preparative scale asymmetric bioreduction of 4-nitroacetophenone (1m) by C. zeylanoides P1 gave (S)-1-(4-nitrophenyl)ethanol (2m) with 89% yield and > 99% enantiomeric excess. Compound 2m has been obtained in an enantiomerically pure and inexpensive form. Additionally, these results indicate that C. zeylanoides P1 is a promising biocatalyst for the synthesis of chiral alcohols in industry. © 2017 Wiley-VHCA AG, Zurich, Switzerlanden_US
dc.identifier.doi10.1002/cbdv.201700121
dc.identifier.issn1612-1872
dc.identifier.issue9
dc.identifier.pmid28746771en_US
dc.identifier.scopus2-s2.0-85028615054en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.201700121
dc.identifier.urihttps://hdl.handle.net/20.500.12403/470
dc.identifier.volume14
dc.identifier.wosWOS:000410558700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag
dc.relation.ispartofChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric reduction
dc.subjectBiocatalysis
dc.subjectBiotransformations
dc.subjectCandida zeylanoides
dc.subjectWhole yeast cells
dc.subject4 nitroacetophenone
dc.subjectalcohol derivative
dc.subject4-nitroacetophenone
dc.subjectacetophenone
dc.subjectacetophenone derivative
dc.subjectbenzyl alcohol derivative
dc.subjectmethylphenyl carbinol
dc.subjectArticle
dc.subjectasymmetric synthesis
dc.subjectbiocatalysis
dc.subjectbiocatalyst
dc.subjectbiotransformation
dc.subjectCandida zeylanoides
dc.subjectchirality
dc.subjectenantiomer
dc.subjectenantioselectivity
dc.subjectenzyme structure
dc.subjectfermentation
dc.subjectnonhuman
dc.subjectorange juice
dc.subjectPichia
dc.subjectPichia fermentans
dc.subjectreduction (chemistry)
dc.subjectSaccharomyces uvarum
dc.subjectstereoselectivity
dc.subjectwhole cell
dc.subjectyeast cell
dc.subjectCandida
dc.subjectchemistry
dc.subjectclassification
dc.subjectfood control
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectoxidation reduction reaction
dc.subjectstereoisomerism
dc.subjectAcetophenones
dc.subjectBenzyl Alcohols
dc.subjectBiocatalysis
dc.subjectCandida
dc.subjectFood Microbiology
dc.subjectIndustrial Microbiology
dc.subjectOxidation-Reduction
dc.subjectStereoisomerism
dc.subjectAsymmetric reduction
dc.subjectBiocatalysis
dc.subjectBiotransformations
dc.subjectCandida zeylanoides
dc.subjectWhole yeast cells
dc.subject4 nitroacetophenone
dc.subjectalcohol derivative
dc.subject4-nitroacetophenone
dc.subjectacetophenone
dc.subjectacetophenone derivative
dc.subjectbenzyl alcohol derivative
dc.subjectmethylphenyl carbinol
dc.subjectArticle
dc.subjectasymmetric synthesis
dc.subjectbiocatalysis
dc.subjectbiocatalyst
dc.subjectbiotransformation
dc.subjectCandida zeylanoides
dc.subjectchirality
dc.subjectenantiomer
dc.subjectenantioselectivity
dc.subjectenzyme structure
dc.subjectfermentation
dc.subjectnonhuman
dc.subjectorange juice
dc.subjectPichia
dc.subjectPichia fermentans
dc.subjectreduction (chemistry)
dc.subjectSaccharomyces uvarum
dc.subjectstereoselectivity
dc.subjectwhole cell
dc.subjectyeast cell
dc.subjectCandida
dc.subjectchemistry
dc.subjectclassification
dc.subjectfood control
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectoxidation reduction reaction
dc.subjectstereoisomerism
dc.subjectAcetophenones
dc.subjectBenzyl Alcohols
dc.subjectBiocatalysis
dc.subjectCandida
dc.subjectFood Microbiology
dc.subjectIndustrial Microbiology
dc.subjectOxidation-Reduction
dc.subjectStereoisomerism
dc.titleHighly Enantioselective Production of Chiral Secondary Alcohols with Candida zeylanoides as a New Whole Cell Biocatalysten_US
dc.typeArticleen_US

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