Relation between monocyte to high-density lipoprotein cholesterol ratio and prognosis in recipients after liver transplantation

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dc.authorid0000-0003-4174-3292
dc.contributor.authorOkutan, Serafettin
dc.contributor.authorSaritas, Hasan
dc.contributor.authorSaritas, Serdar
dc.contributor.authorBulbuloglu, Semra
dc.contributor.authorGunes, Huseyin
dc.date.accessioned2026-02-28T12:17:55Z
dc.date.available2026-02-28T12:17:55Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground The end-stage liver diseases require liver transplantation as the life-saving solution. It is known that monocytes/macrophages and high-density lipoprotein cholesterol (HDLC) have important contributions to the development of hepatic inflammation and oxidative stress before liver transplantation. However, the effect of monocyte/HDL-C ratio (MHR) on clinical progression and outcome in the post-transplant period are not fully understood. Our hypothesis is that the MHR value may be associated with poor vs. good outcomes after liver transplantation. Methods In our retrospective study, we included 464 liver transplant recipients. Patients' data were extracted from electronic and other paper records in our teaching/research hospital. The MHR values and other blood parameters (creatinine, total protein, albumin, etc.) were expressed as a mean and standard deviation, which were analyzed by the Pearson correlation test. The relationship between graft dysfunction and MHR was determined by ROC curve analysis. Results The mean age of liver transplant recipients was 45.8 +/- 13.7 years. Nineteen percent of patients had liver failure due to Alcoholic Fatty Liver Disease (AFLD) and 34.5 % had liver failure due to hepatitis B virus. At the end of 3 months after liver transplantation, 84.5 % of liver transplant recipients were alive, 5.8 % experienced graft rejection and 5.17 % had an infection. There was a statistically significant improvement in total protein, albumin, liver function tests, and serum creatinine values of the survivors (all p < 0.05). The MHR levels were significantly higher in patients who died after transplantation in comparison to those who survived before and after liver transplantation and these differences were statistically significant (p < 0.01). Conclusion The increased MHR values of recipients after liver transplantation correlated with their risk of survival. Furthermore, the MHR value increased with increased MELD score and the number of days of hospitalization and was not affected by gender and age. MHR was higher in patients with chronic diseases. Patients with high MHR before and after transplantation should be monitored more closely in the perioperative period.
dc.identifier.doi10.1016/j.trim.2025.102331
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmid41319886
dc.identifier.scopus2-s2.0-105024248369
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.trim.2025.102331
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6019
dc.identifier.volume93
dc.identifier.wosWOS:001633397400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTransplant Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260218
dc.subjectHigh-density lipoprotein cholesterol
dc.subjectHDL-C
dc.subjectliver transplantation
dc.subjectMHR
dc.subjectMonocyte
dc.subjectRecipients
dc.titleRelation between monocyte to high-density lipoprotein cholesterol ratio and prognosis in recipients after liver transplantation
dc.typeArticle

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