The Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method

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dc.contributor.authorErkilic, T. Orkun
dc.contributor.authorBayraktar, B.
dc.date.accessioned2026-02-28T12:18:10Z
dc.date.available2026-02-28T12:18:10Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: the aim of this study was to investigate the effects of Cannabidiol on myokine (Irisin), cerebral (BDNF) and cardiac (cTnI) responses in sepsis-induced rats by Cecal Ligation Perforation (CLP) method. Methods: In this study, 40 adult male Wistar albino rats, aged between 8-10 weeks, were used. 5 groups were created, with 8 rats in each group: Control (C), Sham (S), CLP, CLP+CBD 2.5 mg/kg, CLP+CBD 5 mg/kg group. Rats in groups C and Sham were sacrificed at the end of the 10th hour and intracardiac blood was taken immediately afterwards. In groups CLP, CLP+2.5 mg/kg, CLP+5 mg/kg, intra-abdominal sepsis was induced and at the end of the 10th( )hour after sepsis occurred with CLP application, rats were sacrificed and intracardiac blood was taken immediately afterwards. Irisin, BDNF and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, mean serum irisin, BDNF and levels were determined to be at the lowest level in the CLP group, while cTnI levels were at the highest level (p<0.01). In CLP groups, serum irisin and BDNF levels increased due to CBD addition and the most significant decrease in cTnI levels occurred in 5 mg/kg CBD groups. As a result, it was concluded that CLP may be safe and beneficial when administered at a dose of 5 mg/kg in sepsis-induced rats.
dc.identifier.doi10.18805/IJAR.BF-1905
dc.identifier.endpage502
dc.identifier.issn0367-6722
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105000365804
dc.identifier.scopusqualityQ3
dc.identifier.startpage497
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1905
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6143
dc.identifier.volume59
dc.identifier.wosWOS:001447426400020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectBrain-derived neurotrophic factor
dc.subjectCannabidiol
dc.subjectCardiac troponin I
dc.subjectCecal ligation perforation
dc.subjectIrisin
dc.subjectRat
dc.subjectSepsis
dc.titleThe Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method
dc.typeArticle

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