LRIG1 levels in chronic rhinosinusitis with nasal polyps

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dc.authoridSahin, Abdulkadir/0000-0002-8426-792X
dc.authoridTavaci Ozcelik, Aysegul/0000-0003-4318-5474
dc.authoridHalici, Zekai/0000-0001-6854-6059
dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorSahin, Abdulkadir
dc.contributor.authorOzcelik, Aysegul Tavaci
dc.contributor.authorHalici, Zekai
dc.date.accessioned2024-10-04T18:51:22Z
dc.date.available2024-10-04T18:51:22Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractPurpose: Nasal polyps (NPs), usually occurring together with chronic rhinosinusitis (CRS), are benign masses of mucosal origin arising from inflammation. The transmembrane protein known as leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) is a member of the Lrig family. Lrig1 is frequently expressed in the respiratory tract and epithelial tissues and can inhibit several signaling pathways involved in cell proliferation. The aim of this study was to determine Lrig1 levels in NP tissues of patients with CRS. Material and Methods: This study included 36 patients with CRS and NPs and 15 patients who underwent rhinoplasty as the control group. The Lrig1 levels of all participants were measured by the ELISA method.Results: This study revealed that Lrig1 levels were significantly lower in NP tissues than in tissues of the control group. The mean level of Lrig1 of the NP tissues was 22.2 ng/ml, while the mean level of the control group was 28.5 ng/ml. According to the results of ROC analysis, Lrig1 levels have the power to distinguish polyp tissues from control tissues (AUC=0.794). Lrig1 levels were higher in tissues with scores of 4-8 than in tissues with scores of 16-20 based on the results of computed tomography scoring. According to endoscopic evaluations, Lrig1 levels of tissues with scores of 5-8 or 9-11 were relatively lower than those of tissues with scores of 2-4.Conclusion: Lrig1 levels were found to be decreased in NP tissues. Thus, Lrig1 may be used to confirm the presence of NPs. Lrig1 may also be helpful in NP grading. Increasing the Lrig1 levels in cases of NPs has the potential to become a targetable treatment modality.en_US
dc.identifier.doi10.17826/cumj.1230714
dc.identifier.endpage329en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2en_US
dc.identifier.startpage323en_US
dc.identifier.trdizinid1197719en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1230714
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197719
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3472
dc.identifier.volume48en_US
dc.identifier.wosWOS:001008335200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNasal polypsen_US
dc.subjectLrig1en_US
dc.subjectELISAen_US
dc.subjectrhinosinusitisen_US
dc.titleLRIG1 levels in chronic rhinosinusitis with nasal polypsen_US
dc.typeArticleen_US

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