The Relationship of Mitochondrial-derived Peptide (MOTS-c) and Brain Mitochondrial Carrier Protein 1 (BMCP1) Response in Sheep with Some Physiological Parameters

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dc.contributor.authorBayraktar, B.
dc.contributor.authorDemir, N.
dc.contributor.authorAksakal, V.
dc.date.accessioned2024-10-04T18:54:00Z
dc.date.available2024-10-04T18:54:00Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBackground: Mitochondria are organelles called power plants of the cell, which are found in eukaryotic cells and are responsible for the production of energy needed by the cells through aerobic respiration. Mitochondrial dysfunction causes endocrinological, cardiovascular, metabolic and neurodegenerative diseases. The aim of this study was to examine the effects of body condition score (BCS), lactation, pregnancy, age and gender on Mitochondrial-Derived Peptide (MOTS-c) and Brain Mitochondrial Transporter Protein 1 (BMCP1) levels in Akkaraman sheep. Methods: Sheep are classified into 3 categories according to BCS (BCS<2, BCS=3-3.5, BCS >= 4). In creating groups in terms of BCS, it was determined by the palpation method applied to the waist area. The sheep included in the study were divided into 4 groups: early lactation, early pregnancy, late pregnancy (dry period) and age (female and male sheep).1(st) group, ewes in the first period of pregnancy (on the 100(th) day of the first pregnancy) (n = 30), 2(nd) group, ewes in the early lactation period (n = 30), 3(rd) group, ewes in the dry period (the last two months of pregnancy) (n = 30) and in the 4(th) group, <2 (young) (n=30), 2-8 (adult) (n=30), 8> (old) (n=30), male and female sheep (n=30) of different ages. =180) total of 270 animals. Blood samples were taken from the jugular vein of the sheep before the morning feeding. MOTSc and BMCP1 levels were determined in blood serum samples by ELISA method. Result: In the study, serum MOTS-c and BMCP1 levels in sheep during lactation and pregnancy were determined to be lowest in the VKS<2 group and highest in the VKS >= 4 groups. Likewise, in age and gender groups, the highest level was detected in young lambs and yearlings in the VKS<2 group, while the highest level was detected in old sheep and rams in the VKS >= 4 group. As a result, it was determined that different age, gender, pregnancy and lactation periods affected serum MOTS-c and BMCP1 levels depending on the change in BCS (P<0.05). It was concluded that MOTS-c and BMCP1 may be useful parameters in the evaluation of mitochondrial function, energy metabolism and metabolic profile.en_US
dc.identifier.doi10.18805/IJAR.BF-1785
dc.identifier.endpage917en_US
dc.identifier.issn0367-6722
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85197305613en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage912en_US
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1785
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3824
dc.identifier.volume58en_US
dc.identifier.wosWOS:001263345700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAgricultural Research Communication Centreen_US
dc.relation.ispartofIndian Journal of Animal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain mitochondrial transporter protein 1 (BMCP1)en_US
dc.subjectMitochondrial-derived peptide (MOTS-c)en_US
dc.subjectPhysiological parametersen_US
dc.subjectSheepen_US
dc.titleThe Relationship of Mitochondrial-derived Peptide (MOTS-c) and Brain Mitochondrial Carrier Protein 1 (BMCP1) Response in Sheep with Some Physiological Parametersen_US
dc.typeArticleen_US

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