Ferulago pauciradiata Boiss. & Heldr. Effects of Prantschimgin Compound Isolated from the Root of the Plant on LPS-Induced Inflammation Model in the L929 Cell Line

Basit Öğe Kaydı
dc.contributor.authorKutlu, Zerrin
dc.contributor.authorUzunçakmak, Sevgi Karabulut
dc.contributor.authorKarakaya, Songül
dc.contributor.authorDelımustafaoglu, Fatmagul
dc.date.accessioned2024-10-04T19:05:22Z
dc.date.available2024-10-04T19:05:22Z
dc.date.issued2021
dc.departmentBayburt Üniversitesien_US
dc.description.abstractInvestigation of the effects of prantchimgin (Prn) compound isolated from the root part of the Ferulago pauciradiata (Apiaceae) plant in the lipopolysaccharide (LPS) cytotoxicity model created in the L929 cell line. L929 cell lines were applied in a 5% CO2 incubator at 37 °C, using standard cell culture procedures, LPS was applied with Prn pure substance with a final concentration of 2 µL and 1 µL after 1 hour. Following the LPS application, the MTT protocol, a colorimetric method, was applied to determine cell viability at the end of the required 24th, 48th, and 72nd hours incubation times. IC50 values were calculated as 0.28 µg/mL for Pnr and 1 µg/mL for LPS. Application of LPS to L929 cell lines caused a significant decrease in cellular index depending on time. Also, in the Prn + LPS groups, it was found that the decreased cell index significantly increased even closer to the control compared to the LPS applied group. It was found that cyctoxicity and cell damage caused by LPS applied to the L929 cell line improved after Pnr application.en_US
dc.identifier.doi10.18185/erzifbed.781919
dc.identifier.endpage713en_US
dc.identifier.issn1307-9085
dc.identifier.issn2149-4584
dc.identifier.issue2en_US
dc.identifier.startpage704en_US
dc.identifier.trdizinid479777en_US
dc.identifier.urihttps://doi.org/10.18185/erzifbed.781919
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/479777
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4374
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleFerulago pauciradiata Boiss. & Heldr. Effects of Prantschimgin Compound Isolated from the Root of the Plant on LPS-Induced Inflammation Model in the L929 Cell Lineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu