Pharmacological Potential and Bioactive Components of Wild Anatolian Sage (Salvia aethiopis L.)

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dc.authorid0000-0001-5974-327X
dc.authorid0000-0002-2343-3672
dc.authorid0000-0002-8445-5082
dc.authorid0000-0001-7100-9318
dc.authorid0000-0001-6193-3734
dc.contributor.authorBilginoglu, Emine
dc.contributor.authorKizil, Hamit Emre
dc.contributor.authorOgutcu, Hatice
dc.contributor.authorAgar, Guleray
dc.contributor.authorBagci, Yavuz
dc.date.accessioned2026-02-28T12:17:40Z
dc.date.available2026-02-28T12:17:40Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractSalvia aethiopis L., a member of the Lamiaceae family, has gained attention due to its bioactive compounds with potential therapeutic applications. This study investigated the chemical composition and biological activities of S. aethiopis ethanol extract collected from Karaman province, T & uuml;rkiye. The phenolic profile of the plant was characterized using LC-MS/MS analysis, which revealed substantial amounts of rosmarinic acid, ferulic acid, caffeic acid, and p-coumaric acid. The antimicrobial activity of the extracts was evaluated against various Gram-positive and Gram-negative bacteria, as well as fungal strains, using the agar well diffusion method. The results demonstrated potent antibacterial effects, particularly against Staphylococcus aureus, Micrococcus luteus, and Klebsiella pneumoniae. Furthermore, the cytotoxic potential of S. aethiopis was assessed on H-460 non-small cell lung cancer cells. The extract exhibited a dose-dependent cytotoxic effect, with a significant reduction in cell viability after 24 and 48 h of treatment, yielding IC50 values of 80.08 and 56.19 mu g/mL, respectively. These findings suggest that S. aethiopis possesses promising antimicrobial and anticancer properties, which could contribute to the development of novel therapeutic agents.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBIdot;TAK)
dc.description.sponsorshipThis work is supported by the Scientific and Technological Research Council of Turkey (TUB & Idot;TAK).
dc.identifier.doi10.1002/fsn3.70118
dc.identifier.issn2048-7177
dc.identifier.issue4
dc.identifier.pmid40144556
dc.identifier.scopus2-s2.0-105001575055
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/fsn3.70118
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5906
dc.identifier.volume13
dc.identifier.wosWOS:001451293600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectantimicrobial activities
dc.subjectchemical characterization
dc.subjectcytotoxicity
dc.subjectSalvia aethiopis L.
dc.titlePharmacological Potential and Bioactive Components of Wild Anatolian Sage (Salvia aethiopis L.)
dc.typeArticle

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