Determination of radioprotective and genotoxic properties of sulfamide derivatives

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dc.authoridKarabulut, Abdulhalik/0000-0003-2290-9007
dc.authoridAygun, Bunyamin/0000-0002-9384-1540
dc.authoridGoksu, Suleyman/0000-0003-1280-3954
dc.authoridALIM, Bunyamin/0000-0002-4143-9787
dc.authoridGulluce, Medine/0000-0002-5957-8259
dc.contributor.authorAygun, Bunyamin
dc.contributor.authorAlaylar, Burak
dc.contributor.authorAkincioglu, Akin
dc.contributor.authorAlim, Bunyamin
dc.contributor.authorKocaman, Ebu Talip
dc.contributor.authorKaradayi, Mehmet
dc.contributor.authorAbu Al-Sayyed, Mohammed Ibrahim
dc.date.accessioned2024-10-04T18:49:27Z
dc.date.available2024-10-04T18:49:27Z
dc.date.issued2021
dc.departmentBayburt Üniversitesien_US
dc.description.abstractSome potential drug active substances with the ability to reduce the effects of radiation on human tissues and cells were investigated. For this purpose, eight different types of sulfamide derivatives were synthesized and nuclear radiation protection parameters were determined. Neutron radiation reduction parameters such as the half-value layer effective removal cross-sections, mean free path, and the number of particles passing through the sample were determined with GEANT4 code. Additionally, the gamma radiation attenuation parameters of the materials examined were determined using Phy-X/PSD software in the energy area of 0.015-15 MeV. These parameters are the half-value layer, mass attenuation coefficient, mean free path, exposure buildup factor and effective atomic number. Neutron radiation absorption experiments were applied using an Am-241-Be fast neutron source. All results obtained for neutron radiation were compared with paraffin and water. It has been found that the ability of sulfamide derivatives to absorb these radiations is superior to reference materials. To determine whether these derivatives could have adverse effects on human health, their genotoxic potential was determined using the Ames/Salmonella bacterial reversion test. The results showed that these derivatives can be considered genotoxically safe in tests at concentrations up to 5 mM. Thus, it is suggested that the derivative materials examined in this study can be used as active substances for a drug to be made for protection against both neutron and gamma radiation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T881]; Ataturk Universityen_US
dc.description.sponsorshipThe authors are indebted to the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No. 112T881) and Ataturk University for their financial support of this work.en_US
dc.identifier.doi10.1515/ract-2021-1088
dc.identifier.endpage904en_US
dc.identifier.issn0033-8230
dc.identifier.issn2193-3405
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85118487859en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage891en_US
dc.identifier.urihttps://doi.org/10.1515/ract-2021-1088
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3159
dc.identifier.volume109en_US
dc.identifier.wosWOS:000744642300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmes testen_US
dc.subjectgammaen_US
dc.subjectneutronen_US
dc.subjectsulfamideen_US
dc.subjectsulfamoyl carbamateen_US
dc.titleDetermination of radioprotective and genotoxic properties of sulfamide derivativesen_US
dc.typeArticleen_US

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