Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1? in SARS-Cov-2 infected patients

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dc.authoridKerget, Ferhan/0000-0002-5160-4854
dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorNaldan, Muhammet Emin
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorKerget, Ferhan
dc.contributor.authorHalici, Zekai
dc.date.accessioned2024-10-04T18:52:41Z
dc.date.available2024-10-04T18:52:41Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBackground Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1 alpha lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients. Materials and Results We extracted RNA from peripheral blood samples of COVID-19(+) and COVID-19(-) individuals. The real-time PCR method was used to measure mRNA expression of PAPP-A, STC-2, and HIF-1 alpha. Gene expression analysis was evaluated by the 2(-Delta Delta Ct) method. PAPP-A, STC-2, and HIF-1 alpha mRNA expressions of severe patients were higher than healthy individuals (p = 0.0451, p= 0.4466, p < 0.0001, respectively). Correlation analysis of gene expression patterns of severe patients demonstrated a positive correlation between PAPP-A and STC-2 (p <0.0001, r= 0.8638). Conclusion This is the first study that investigates the relation of PAPP-A, STC-2, and HIF-1 alpha gene expression in patients with COVID-19 infection. Besides the routine laboratory findings, PAPP-A, STC-2, and HIF-1 alpha mRNA expressions may be considered to patients' prognosis as a sign of increased cytokines and pro-inflammatory molecules.en_US
dc.identifier.doi10.1007/s11033-022-07710-9
dc.identifier.endpage8699en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue9en_US
dc.identifier.pmid35796937en_US
dc.identifier.scopus2-s2.0-85133624726en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8693en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-022-07710-9
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3614
dc.identifier.volume49en_US
dc.identifier.wosWOS:000825011800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSARS-CoV-2en_US
dc.subjectPAPP-Aen_US
dc.subjectSTC-2en_US
dc.subjectHIF-1 alphaen_US
dc.subjectCOVID-19en_US
dc.titlePreliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1? in SARS-Cov-2 infected patientsen_US
dc.typeArticleen_US

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