Thiol disulfide homeostasis in primary dysmenorrhea

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dc.authoridKASKO ARICI, Yeliz/0000-0001-6820-0381
dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.contributor.authorSavrun, Atakan
dc.contributor.authorSavrun, Seyda Tuba
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorGokcen, Emre
dc.contributor.authorArici, Yeliz Kasko
dc.contributor.authorAygun, Ali
dc.contributor.authorKorkmaz, Vakkas
dc.date.accessioned2024-10-04T18:54:04Z
dc.date.available2024-10-04T18:54:04Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractOxidative stress is defined as a result of the loss of balance between the production of free radical or reactive oxygen species and the antioxidant system. This study aimed to determine the level of thiol-disulfide homeostasis (TDH) in the serum of women with primary dysmenorrhea. The study group consisted of 42 subjects with primary dysmenorrhea, and the control group consisted of 30 volunteer women with demographic characteristics similar to the study group. Native thiol (SH), total thiol (TSH), disulphide (SS), and SH/SS parameters were measured for TDH of the subjects. The SH (p = 0.038) and SH/TSH (p = 0.046) levels were significantly higher while SS (p = 0.013), SS/SH (p = 0.042) and SS/TSH (p = 0.046) levels were lower in the study group than in the healthy control group. The SS cut-off value was determined as 17.85 in the study group (sensitivity = 61.9%, specificity = 43.3%). Therefore, the probability of dysmenorrhea may increase significantly when SS levels fall below this value. In subjects with dysmenorrhea, there was a decrease in SS levels and an increase in SH levels in order to protect the cells and tissues from the harmful effects of free radicals.en_US
dc.identifier.doi10.22514/sv.2021.151
dc.identifier.endpage103en_US
dc.identifier.issn1334-5605
dc.identifier.issn1845-206X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85127212839en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.22514/sv.2021.151
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3849
dc.identifier.volume18en_US
dc.identifier.wosWOS:000766748100012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.ispartofSigna Vitaeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary dysmenorrheaen_US
dc.subjectThiol-disulfideen_US
dc.subjectOxidative stressen_US
dc.subjectROC analysisen_US
dc.subjectTDHen_US
dc.titleThiol disulfide homeostasis in primary dysmenorrheaen_US
dc.typeArticleen_US

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