Investigation of neutron and gamma radiation protective characteristics of synthesized quinoline derivatives

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dc.authoridAygun, Bunyamin/0000-0002-9384-1540
dc.authoridALIM, Bunyamin/0000-0002-4143-9787
dc.authoridGulluce, Medine/0000-0002-5957-8259
dc.authoridTURHAN, KADIR/0000-0002-7718-1618
dc.authoridKarabulut, Abdulhalik/0000-0003-2290-9007
dc.contributor.authorAygun, Bunyamin
dc.contributor.authorAlaylar, Burak
dc.contributor.authorTurhan, Kadir
dc.contributor.authorSakar, Erdem
dc.contributor.authorKaradayi, Mehmet
dc.contributor.authorAbu Al-Sayyed, Ibrahim
dc.contributor.authorPelit, Emel
dc.date.accessioned2024-10-04T18:51:13Z
dc.date.available2024-10-04T18:51:13Z
dc.date.issued2020
dc.departmentBayburt Üniversitesien_US
dc.description.abstractPurpose: Quinoline is formed by various natural compounds, such as alkaloids from the cinchona plant, which exhibit various biological activities, and is an important building material for the development of new drugs. Quinoline can be used in anti-radiation drug development but radiation interaction properties must be determined. Material and methods: In this study, six types of synthesized quinoline derivatives were used. Fast neutron removal cross-section, mean free path, half value layer and transmission number were theoretically determined by using GEometry ANd Tracking 4 and FLUktuierende KAskade simulation codes for neutron shielding. Neutron dose absorption rates were determined using the(241)Am-Be fast neutron source and the Canberra NP series portable BF(3)gas proportional neutron detector. Gamma radiation shielding parameters were determined by using WinXCom and PSY-X/PSD software. Additionally, the genotoxic potentials of the derivatives were assessed by using the Ames/Salmonellabacterial reversion assay. Results and conclusions: Neutron shielding parameters such as removal cross-section, mean free path, half value layer and transmission number were theoretically determined for fast neutrons. To determine neutron absorption capacity of quinoline derivatives, neutron absorption, experiments were conducted. In addition, gamma radiation shielding parameters were calculated such as the mean free path (MFP), mass attenuation coefficient (mu t), half value thickness layer (HVL) and effective atomic number (Zeff) in the energy range of 0.015-15 MeV. The results of the all quinoline derivatives have excellent fast neutron shielding power compared to ordinary concrete. In addition, all quinoline derivatives have been found to have the capacity to attenuate gamma radiation. Moreover, they absorb well in both types of radiation, do not cause secondary radiation, and they are genotoxically safe at the tested concentrations. This study has demonstrated that these products can be used as active ingredients for a drug to be developed against radiation.en_US
dc.identifier.doi10.1080/09553002.2020.1811421
dc.identifier.endpage1434en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue11en_US
dc.identifier.pmid32813583en_US
dc.identifier.scopus2-s2.0-85091074141en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1423en_US
dc.identifier.urihttps://doi.org/10.1080/09553002.2020.1811421
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3428
dc.identifier.volume96en_US
dc.identifier.wosWOS:000569449200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrugsen_US
dc.subjectgenotoxicityen_US
dc.subjectgammaen_US
dc.subjectneutronen_US
dc.subjectshieldingen_US
dc.subjectquinoline derivativesen_US
dc.titleInvestigation of neutron and gamma radiation protective characteristics of synthesized quinoline derivativesen_US
dc.typeArticleen_US

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