Highly Enantioselective Production of Chiral Secondary Alcohols Using Lactobacillus paracasei BD101 as a New Whole Cell Biocatalyst and Evaluation of Their Antimicrobial Effects

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dc.authorid57196075359
dc.authorid37098938400
dc.authorid36815706500
dc.contributor.authorYılmaz D.
dc.contributor.authorŞahin E.
dc.contributor.authorDertli E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:13Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:13Z
dc.date.issued2017
dc.departmentBayburt Üniversitesien_US
dc.description.abstractChiral secondary alcohols are valuable intermediates for many important enantiopure pharmaceuticals and biologically active molecules. In this work, we studied asymmetric reduction of aromatic ketones to produce the corresponding chiral secondary alcohols using lactic acid bacteria (LAB) as new biocatalysts. Seven LAB strains were screened for their ability to reduce acetophenones to their corresponding alcohols. Among these strains, Lactobacillus paracasei BD101 was found to be the most successful at reducing the ketones to the corresponding alcohols. The reaction conditions were further systematically optimized for this strain and high enantioselectivity (99%) and very good yields were obtained. These secondary alcohols were further tested for their antimicrobial activities against important pathogens and significant levels of antimicrobial activities were observed although these activities were altered depending on the secondary alcohols as well as their enantiomeric properties. The current methodology demonstrates a promising and alternative green approach for the synthesis of chiral secondary alcohols of biological importance in a cheap, mild, and environmentally useful process. © 2017 Wiley-VHCA AG, Zurich, Switzerlanden_US
dc.identifier.doi10.1002/cbdv.201700269
dc.identifier.issn1612-1872
dc.identifier.issue11
dc.identifier.pmid28792667en_US
dc.identifier.scopus2-s2.0-85031725613en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.201700269
dc.identifier.urihttps://hdl.handle.net/20.500.12403/458
dc.identifier.volume14
dc.identifier.wosWOS:000416313000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag
dc.relation.ispartofChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial
dc.subjectBiocatalyst
dc.subjectChiral alcohols
dc.subjectEnantioselective bioreduction
dc.subjectLactobacillus paracasei
dc.subjectacetophenone derivative
dc.subjectalcohol derivative
dc.subjectketone derivative
dc.subjectalcohol derivative
dc.subjectantiinfective agent
dc.subjectalcohol production
dc.subjectantimicrobial activity
dc.subjectArticle
dc.subjectasymmetric catalysis
dc.subjectBacillus cereus
dc.subjectbacterial strain
dc.subjectbiocatalyst
dc.subjectchirality
dc.subjectconcentration (parameters)
dc.subjectenantiomer
dc.subjectenantioselectivity
dc.subjectEnterococcus faecium
dc.subjectEscherichia coli
dc.subjectevaluation study
dc.subjectlactic acid bacterium
dc.subjectLactobacillus fermentum
dc.subjectLactobacillus paracasei
dc.subjectLactobacillus plantarum
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectquantum yield
dc.subjectreduction (chemistry)
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectStaphylococcus aureus
dc.subjecttemperature sensitivity
dc.subjectYersinia enterocolitica
dc.subjectbiocatalysis
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectenzyme specificity
dc.subjectGram negative bacterium
dc.subjectGram positive bacterium
dc.subjectLactobacillus paracasei
dc.subjectmetabolism
dc.subjectmicrobial sensitivity test
dc.subjectoxidation reduction reaction
dc.subjectpH
dc.subjectstereoisomerism
dc.subjecttemperature
dc.subjecttime factor
dc.subjectAcetophenones
dc.subjectAlcohols
dc.subjectAnti-Infective Agents
dc.subjectBiocatalysis
dc.subjectGram-Negative Bacteria
dc.subjectGram-Positive Bacteria
dc.subjectHydrogen-Ion Concentration
dc.subjectLactobacillus paracasei
dc.subjectMicrobial Sensitivity Tests
dc.subjectOxidation-Reduction
dc.subjectStereoisomerism
dc.subjectSubstrate Specificity
dc.subjectTemperature
dc.subjectTime Factors
dc.subjectAntibacterial
dc.subjectBiocatalyst
dc.subjectChiral alcohols
dc.subjectEnantioselective bioreduction
dc.subjectLactobacillus paracasei
dc.subjectacetophenone derivative
dc.subjectalcohol derivative
dc.subjectketone derivative
dc.subjectalcohol derivative
dc.subjectantiinfective agent
dc.subjectalcohol production
dc.subjectantimicrobial activity
dc.subjectArticle
dc.subjectasymmetric catalysis
dc.subjectBacillus cereus
dc.subjectbacterial strain
dc.subjectbiocatalyst
dc.subjectchirality
dc.subjectconcentration (parameters)
dc.subjectenantiomer
dc.subjectenantioselectivity
dc.subjectEnterococcus faecium
dc.subjectEscherichia coli
dc.subjectevaluation study
dc.subjectlactic acid bacterium
dc.subjectLactobacillus fermentum
dc.subjectLactobacillus paracasei
dc.subjectLactobacillus plantarum
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectquantum yield
dc.subjectreduction (chemistry)
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectStaphylococcus aureus
dc.subjecttemperature sensitivity
dc.subjectYersinia enterocolitica
dc.subjectbiocatalysis
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectenzyme specificity
dc.subjectGram negative bacterium
dc.subjectGram positive bacterium
dc.subjectLactobacillus paracasei
dc.subjectmetabolism
dc.subjectmicrobial sensitivity test
dc.subjectoxidation reduction reaction
dc.subjectpH
dc.subjectstereoisomerism
dc.subjecttemperature
dc.subjecttime factor
dc.subjectAcetophenones
dc.subjectAlcohols
dc.subjectAnti-Infective Agents
dc.subjectBiocatalysis
dc.subjectGram-Negative Bacteria
dc.subjectGram-Positive Bacteria
dc.subjectHydrogen-Ion Concentration
dc.subjectLactobacillus paracasei
dc.subjectMicrobial Sensitivity Tests
dc.subjectOxidation-Reduction
dc.subjectStereoisomerism
dc.subjectSubstrate Specificity
dc.subjectTemperature
dc.subjectTime Factors
dc.titleHighly Enantioselective Production of Chiral Secondary Alcohols Using Lactobacillus paracasei BD101 as a New Whole Cell Biocatalyst and Evaluation of Their Antimicrobial Effectsen_US
dc.typeArticleen_US

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