Green Synthesis, Characterization, Antioxidant, Antibacterial and Enzyme Inhibition Effects of Chestnut (Castanea sativa) Honey-Mediated Silver Nanoparticles

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dc.authoridKeskin, Merve/0000-0001-9365-334X
dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.authoridKurek-Gorecka, Anna/0000-0002-2006-6715
dc.authoridOlczyk, Pawel/0000-0001-7387-9587
dc.contributor.authorKeskin, Merve
dc.contributor.authorKaya, Gulsen
dc.contributor.authorBayram, Sinan
dc.contributor.authorKurek-Gorecka, Anna
dc.contributor.authorOlczyk, Pawel
dc.date.accessioned2024-10-04T18:51:03Z
dc.date.available2024-10-04T18:51:03Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIn this study, chestnut honey-based silver nanoparticles (CH-AgNPs) were synthesized at different temperatures (30, 60 and 90 degrees C) and these nanoparticles were characterized by different techniques such as UV-vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). The DPPH free radical scavenging assay was used to determine the antioxidant activity of the obtained nanoparticles. The inhibition effects of these nanoparticles for some clinically important enzymes such as myeloperoxidase and collagenase were investigated. In addition, the disk diffusion method (DDM), agar well diffusion (AWD), and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) techniques were used to determine the antibacterial activity of CH-AgNPs. In honey-based silver nanoparticle production processes using green synthesis, it was determined that the nanoparticle sizes decreased from 55 to 27 nm with an increase in temperature. In addition, it was determined that the rate of inhibition of myeloperoxidase (36.4% to 34.0%) and collagenase enzymes (74.2% to 68.7%) increased with a decrease in particle size. As a result of the antibacterial activity tests, it was observed that CH-AgNPs have antibacterial activity against all target pathogens including Gram-positive and Gram-negative bacteria. The obtained results show that CH-AgNPs produced using chestnut honey have the potential to be used in fields such as medicine, pharmacy and cosmetic technology.en_US
dc.description.sponsorshipMedical University of Silesia, Katowice [PCN-1-059/N/1/F]en_US
dc.description.sponsorshipThis study was supported by a grant from the Medical University of Silesia, Katowice (No. PCN-1-059/N/1/F).en_US
dc.identifier.doi10.3390/molecules28062762
dc.identifier.issn1420-3049
dc.identifier.issue6en_US
dc.identifier.pmid36985734en_US
dc.identifier.scopus2-s2.0-85151331998en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/molecules28062762
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3359
dc.identifier.volume28en_US
dc.identifier.wosWOS:000958171700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgreen synthesisen_US
dc.subjecthoneyen_US
dc.subjectsilveren_US
dc.subjectantioxidanten_US
dc.subjectantibacterialen_US
dc.subjectenzyme inhibitionen_US
dc.titleGreen Synthesis, Characterization, Antioxidant, Antibacterial and Enzyme Inhibition Effects of Chestnut (Castanea sativa) Honey-Mediated Silver Nanoparticlesen_US
dc.typeArticleen_US

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