Green synthesis of enantiopure (S)?1?(benzofuran?2?yl)ethanol by whole?cell biocatalyst

Basit Öğe Kaydı
dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.date.accessioned2020-11-25T18:59:09Z
dc.date.available2020-11-25T18:59:09Z
dc.date.issued2019en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractOptically active aromatic alcohols are valuable chiral building blocks of many natural products and chiral drugs. Lactobacillus paracasei BD87E6, which was isolated from a cereal‐based fermented beverage, was shown as a biocatalyst for the bioreduction of 1‐(benzofuran‐2‐yl) ethanone to (S)‐1‐(benzofuran‐2‐yl) ethanol with highly stereoselectivity. The bioreduction conditions were optimized using L. paracasei BD87E6 to obtain high enantiomeric excess (ee) and conversion. After optimization of the bioreduction conditions, it was shown that the bioreduction of 1‐(benzofuran‐2‐yl)ethanone was performed in mild reaction conditions. The asymmetric bioreduction of the 1‐(benzofuran‐2‐yl)ethanone had reached 92% yield with ee of higher than 99.9% at 6.73 g of substrate. Our study gave the first example for enantiopure production of (S)‐1‐(benzofuran‐2‐yl)ethanol by a biological green method. This process is also scalable and has potential in application. In this study, a basic and novel whole‐cell mediated biocatalytic method was performed for the enantiopure production of (S)‐1‐(benzofuran‐2‐yl)ethanol in the aqueous medium, which empowered the synthesis of a precious chiral intermediary process to be converted into a sophisticated molecule for drug production.en_US
dc.identifier.citationŞahin, E. (2019). Green synthesis of enantiopure (S)‐1‐(benzofuran‐2‐yl) ethanol by whole‐cell biocatalyst. Chirality, 31(10), 892-897.en_US
dc.identifier.doi10.1002/chir.23123
dc.identifier.endpage897en_US
dc.identifier.issue10en_US
dc.identifier.pmid31423658en_US
dc.identifier.scopus2-s2.0-85070832471en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage892en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/chir.23123?casa_token=__wFiBdC-KwAAAAA%3A8kWwh8vOYT_W1dNa1ao1LBrx8LpmGK2TgpN6E0i96f0DtQdglI5dkqb7dR2OfbDCToBBpwlmu5O913s9
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2215
dc.identifier.volume31en_US
dc.identifier.wosWOS:000482255500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChiralityen_US
dc.relation.ispartofChiralityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectChiralityen_US
dc.titleGreen synthesis of enantiopure (S)?1?(benzofuran?2?yl)ethanol by whole?cell biocatalysten_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Beslenme ve Diyetetik Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu