Optimization of Biocatalytic Production of Enantiopure (S)-1-(4-Methoxyphenyl) Ethanol with Lactobacillus senmaizuke Using the Box-Behnken Design-Based Model

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dc.contributor.authorKavi, Mervenur
dc.contributor.authorOzdemir, Akin
dc.contributor.authorDertli, Enes
dc.contributor.authorSahin, Engin
dc.date.accessioned2024-10-04T18:52:33Z
dc.date.available2024-10-04T18:52:33Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractEnantiomerically pure (S)-1-(4-methoxyphenyl) ethanol is a significant molecule for the production of various drug intermediates. (S)-1-(4-methoxyphenyl) ethanol was synthesized from 4-methoxyacetophenone using Lactobacillus senmaizuke as a biocatalyst. In addition, optimization of experimental conditions is important to analyze the role of culture parameters for catalytic bioreduction reactions. For this particular purpose, the experimental conditions of pH, incubation period, temperature, and agitation speed were investigated with the Box-Behnken experimental design-based proposed optimization model. (S)-1-(4-methoxyphenyl) ethanol, which can be used for the synthesis of antihistamines, including diphenhydramine hydrochloride and loratadine cycloalkyl [b] indoles that have the treatment function for an allergic response, was obtained in > 99% conversion, > 99% enantiomeric excess and 96% yield with whole cells of L. senmaizukei at this optimization conditions: pH = 5.80, the temperature = 29 degrees C, incubation period = 50 h, and agitation speed = 155 rpm. The bioreduction of 4-methoxyacetophenone efficiency was importantly affected by the quadratic and linear effects of experimental design parameters. Besides, the results demonstrate the importance of design parameters for catalytic bioreduction reactions. It is also concluded that the results show the effectiveness of the Box-Behnken experimental design-based proposed model to obtain optimum operating conditions of design parameters for catalytic bioreduction reactions.en_US
dc.identifier.doi10.1007/s13369-021-05769-3
dc.identifier.endpage5858en_US
dc.identifier.issn2193-567X
dc.identifier.issn2191-4281
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85107528023en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5849en_US
dc.identifier.urihttps://doi.org/10.1007/s13369-021-05769-3
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3548
dc.identifier.volume47en_US
dc.identifier.wosWOS:000658618500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArabian Journal For Science and Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBox-Behnken designen_US
dc.subjectOptimizationen_US
dc.subjectAsymmetric bioreductionen_US
dc.subjectBiocatalystsen_US
dc.subject(S)-1-(4-Methoxyphenyl) ethanolen_US
dc.titleOptimization of Biocatalytic Production of Enantiopure (S)-1-(4-Methoxyphenyl) Ethanol with Lactobacillus senmaizuke Using the Box-Behnken Design-Based Modelen_US
dc.typeArticleen_US

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