Production of enantiomerically pure (S)-phenyl(pyridin-2-yl)methanol with Lactobacillus paracasei BD101

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.contributor.authorSerencam, Hüseyin
dc.contributor.authorDertli, Enes
dc.date.accessioned2020-11-25T19:58:17Z
dc.date.available2020-11-25T19:58:17Z
dc.date.issued2019en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractAsymmetric reduction studies of heteroaryl ketones, including phenyl(pyridin-2-yl)methanone in enantioselective form with biocatalysts are very few, and chiral heteroaryl alcohols have been synthesized generally in the small scale. In this study, seven bacterial strains have been used to produce the (S)-phenyl(pyridin-2-yl)methanol in high enantiomeric excess and yield. Among the tested strains, Lactobacillus paracasei BD101, was found to be the best biocatalyst for the reducing phenyl(pyridin-2-yl)methanone to the (S)-phenyl(pyridin-2-yl)methanol at gram scale. The asymmetric bioreduction conditions were systematically optimized using L. paracasei BD101, which demonstrated excellent enantioselectivity and high level of conversion for the bioreduction reaction. (S)-phenyl(pyridin-2-yl)methanol, which is an analgesic, was produced enantiomerically pure form in the first time on gram scale using a biocatalyst. In total, 5.857 g of (S)-phenyl(pyridin-2-yl)methanol in enantiomerically pure form (>99% enantiomeric excess) was obtained in 52 h with 93% yield using whole cells of L. paracasei BD101. Enantiomerically pure (S)-phenyl (pyridin-2-yl)methanol, which is an analgesic, was first produced in the gram scale using a biocatalyst with excellent ee (>99%) and yield (93%).en_US
dc.identifier.citationŞahin, E., Serencam, H., & Dertli, E. (2019). Production of enantiomerically pure (S)-phenyl (pyridin-2-yl) methanol with Lactobacillus paracasei BD101. Biocatalysis and Biotransformation, 37(6), 448-454.en_US
dc.identifier.doi10242422.2019.1602611
dc.identifier.endpage454en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85065652258en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage448en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10242422.2019.1602611?casa_token=jJmNDvcqM3MAAAAA%3AJiXv5YrAm94IfC1WII6vfDLBgu6cp1_wLquy0yeHDGaLQyaqFAuK0N8_ONDWrxWPVPFYkv0hiKmDcZ0
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2230
dc.identifier.volume37en_US
dc.identifier.wosWOS:000470500000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiocatalysis and Biotransformationen_US
dc.relation.ispartofBiocatalysis and Biotransformationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectChirality, enantioselectivity, biocatalyst, L. paracasei BD101, (S)-phenyl(pyridin-2-yl)methanolen_US
dc.titleProduction of enantiomerically pure (S)-phenyl(pyridin-2-yl)methanol with Lactobacillus paracasei BD101en_US
dc.typeArticleen_US

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