Evaluation of photon interaction parameters of Anti-HIV drugs

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dc.authoridOzpolat, Ozgur Firat/0000-0002-4533-4368
dc.authoridAKBABA, UGUR/0000-0002-7043-0749
dc.authoridALIM, Bunyamin/0000-0002-4143-9787
dc.authoridSakar, Erdem/0000-0002-1359-4464
dc.contributor.authorAkbaba, Ugur
dc.contributor.authorSakar, Erdem
dc.contributor.authorSayyed, M. I.
dc.contributor.authorAlim, Bunyamin
dc.contributor.authorOzpolat, Ozgur Firat
dc.date.accessioned2024-10-04T18:49:47Z
dc.date.available2024-10-04T18:49:47Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractMedical treatment inevitably exposes individuals to radiation, including those taking drugs used to treat and prevent human immunodeficiency virus (HIV). Motivated by this, we investigated the radiation interaction properties of several HIV drugs to determine the interaction parameters, mass attenuation coefficient (MAC), atomic cross section (ACS), electronic cross section (ECS), effective atomic numbers (Z(eff)), and effective electron density (N-eff). We calculated the values using the Phy-X/PSD software in the range of 0.015-15 MeV. Additionally, we calculated the exposure build-up factor (EBF), and energy absorption build-up factor (EABF) values of the drugs up to 40 mean free path (MFP) using the geometric progression (G-P) method. From our findings, we determined that Combivir, with its relatively high heavy element content, had the highest radiation attenuation capacity, whereas the probability of Lopinavir interacting with photons was the lowest compared with the other drugs. The results of the EBF and EABF parameters, including the scattering effects, ordered the drugs opposite to the primary interaction parameters such as MAC, ACS, ECS, and Z(eff). These findings can guide the treatment process of HIV-positive patients and inform HIV prevention practices conducted alongside radiotherapy, as the interaction between radiation and a drug may cause deterioration in the drug's structure.en_US
dc.identifier.doi10.1016/j.radphyschem.2022.110441
dc.identifier.issn0969-806X
dc.identifier.issn1879-0895
dc.identifier.scopus2-s2.0-85135933318en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.radphyschem.2022.110441
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3283
dc.identifier.volume201en_US
dc.identifier.wosWOS:000892143600004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofRadiation Physics and Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhoton-matter interactionsen_US
dc.subjectHIV drugsen_US
dc.subjectMass attenuationen_US
dc.subjectPhy-X/PSDen_US
dc.subjectBuild-up factoren_US
dc.titleEvaluation of photon interaction parameters of Anti-HIV drugsen_US
dc.typeArticleen_US

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