Methoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer properties

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dc.authoridDirican, Ebubekir/0000-0001-9260-5223
dc.contributor.authorKandemir, Hakan
dc.contributor.authorIzgi, Samet
dc.contributor.authorCinar, Irfan
dc.contributor.authorCebeci, Fatma
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorSaglam, Mehmet F.
dc.contributor.authorSengul, Ibrahim F.
dc.date.accessioned2024-10-04T18:51:25Z
dc.date.available2024-10-04T18:51:25Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIndole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing H-1 NMR, C-13 NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu; Tekirdag Namik Kemal University [NKUBAP.01, 19.220]; Scientific and Technological Research Council of Turkey [120Z116]en_US
dc.description.sponsorshipNAMIK KEMAL UNIVERSITESI; Turkiye Bilimsel ve Teknolojik Arastirma Kurumu; Tekirdag Namik Kemal University, Grant/Award Number: NKUBAP.01. GA.19.220; The Scientific and Technological Research Council of Turkey, Grant/Award Number: 120Z116en_US
dc.identifier.doi10.1002/jhet.4562
dc.identifier.endpage85en_US
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85137568357en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4562
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3485
dc.identifier.volume60en_US
dc.identifier.wosWOS:000852569600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Heterocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiinflammatory Activityen_US
dc.subjectIndole Alkaloidsen_US
dc.subjectInhibitorsen_US
dc.subjectDerivativesen_US
dc.titleMethoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer propertiesen_US
dc.typeArticleen_US

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