Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion- detorsion
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Physiological Soc. and Korean Soc. of Pharmacology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD- 50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720o degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1?) and tumor necrosis factor alpha (TNF-?) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/ R damage on testes caused by torsion-detorsion. © Copyright Korean J Physiol Pharmacol.
Açıklama
Anahtar Kelimeler
Etoricoxib, Gene expression, Ischemia-reperfusion, Torsion-detorsion, etoricoxib, glutathione, glutathione reductase, interleukin 1beta, malonaldehyde, myeloperoxidase, tumor necrosis factor, animal experiment, animal model, animal tissue, antiinflammatory activity, antioxidant activity, Article, controlled study, drug dose comparison, gene expression, histopathology, male, nonhuman, oxidative stress, rat, reperfusion injury, testis injury, testis torsion, Etoricoxib, Gene expression, Ischemia-reperfusion, Torsion-detorsion, etoricoxib, glutathione, glutathione reductase, interleukin 1beta, malonaldehyde, myeloperoxidase, tumor necrosis factor, animal experiment, animal model, animal tissue, antiinflammatory activity, antioxidant activity, Article, controlled study, drug dose comparison, gene expression, histopathology, male, nonhuman, oxidative stress, rat, reperfusion injury, testis injury, testis torsion
Kaynak
Korean Journal of Physiology and Pharmacology
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
5
