Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion- detorsion

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dc.authorid22137189200
dc.authorid55328743400
dc.authorid56306448200
dc.authorid55773098400
dc.authorid56736585200
dc.authorid6507925822
dc.authorid36871648100
dc.contributor.authorYapanoglu T.
dc.contributor.authorOzkaya F.
dc.contributor.authorYilmaz A.H.
dc.contributor.authorMammadov R.
dc.contributor.authorCimen F.K.
dc.contributor.authorHirik E.
dc.contributor.authorAltuner D.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:16Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:16Z
dc.date.issued2017
dc.departmentBayburt Üniversitesien_US
dc.description.abstractEtoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD- 50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720o degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1?) and tumor necrosis factor alpha (TNF-?) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/ R damage on testes caused by torsion-detorsion. © Copyright Korean J Physiol Pharmacol.en_US
dc.identifier.doi10.4196/kjpp.2017.21.5.457
dc.identifier.endpage464
dc.identifier.issn1226-4512
dc.identifier.issue5
dc.identifier.startpage457
dc.identifier.urihttps://dx.doi.org/10.4196/kjpp.2017.21.5.457
dc.identifier.urihttps://hdl.handle.net/20.500.12403/479
dc.identifier.volume21
dc.language.isoenen_US
dc.publisherKorean Physiological Soc. and Korean Soc. of Pharmacology
dc.relation.ispartofKorean Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEtoricoxib
dc.subjectGene expression
dc.subjectIschemia-reperfusion
dc.subjectTorsion-detorsion
dc.subjectetoricoxib
dc.subjectglutathione
dc.subjectglutathione reductase
dc.subjectinterleukin 1beta
dc.subjectmalonaldehyde
dc.subjectmyeloperoxidase
dc.subjecttumor necrosis factor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdrug dose comparison
dc.subjectgene expression
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectreperfusion injury
dc.subjecttestis injury
dc.subjecttestis torsion
dc.subjectEtoricoxib
dc.subjectGene expression
dc.subjectIschemia-reperfusion
dc.subjectTorsion-detorsion
dc.subjectetoricoxib
dc.subjectglutathione
dc.subjectglutathione reductase
dc.subjectinterleukin 1beta
dc.subjectmalonaldehyde
dc.subjectmyeloperoxidase
dc.subjecttumor necrosis factor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdrug dose comparison
dc.subjectgene expression
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectreperfusion injury
dc.subjecttestis injury
dc.subjecttestis torsion
dc.titleEffect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion- detorsionen_US
dc.typeArticleen_US

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