Eumelanin protects the liver against diethylnitrosamine-induced liver injury

Basit Öğe Kaydı
dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.contributor.authorAltindag, Fikret
dc.contributor.authorBogoksayan, Seda
dc.contributor.authorBayram, Sinan
dc.date.accessioned2024-10-04T18:49:45Z
dc.date.available2024-10-04T18:49:45Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThis study aims to evaluate in vivo protective effects of eumelanin (EU) on diethylnitrosamine (DEN)-induced liver injury. Wistar albino male rats were divided into 6 groups (n = 6), Control, DMSO, DEN, DEN + EU10, DEN + EU15, and DEN + EU20. Animals in the DEN group were injected i.p a single dose of 200 mg/kg DEN, DEN + EU10 group was given 10 mg/kg EU, DEN + EU15 group was given 15 mg/kg, DEN + EU20 group was given 20 mg/kg EU for a week. The results showed that there was no significant difference in vessel volume density between the groups. Inflammatory cell infiltration, hydropic degeneration, and necrotic cells were observed in the DEN group, and these histopathological changes were significantly reduced in all treatment groups. Although there was a low intensity of PAS-positive staining in the DEN groups, moderate staining was observed in the treatment groups. While Caspase-3, PCNA, TNF-alpha, and IL-6 expressions increased in the DEN group, their expressions decreased in the EU-treated groups. DEN increased AST, ALT, and MDA levels and decreased CAT levels. In particular, the EU10 dose significantly improved these parameters. The present study revealed that eumelanin has protective effects against DEN-induced liver injury.en_US
dc.description.sponsorshipScientific Research Project Coordination Center of Van Yuzuncu Yil University [TYL-2021-9495]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Coordination Center of Van Yuzuncu Yil University as Project no. TYL-2021-9495.en_US
dc.identifier.doi10.1016/j.tox.2022.153311
dc.identifier.issn0300-483X
dc.identifier.issn1879-3185
dc.identifier.pmid36113623en_US
dc.identifier.scopus2-s2.0-85138359948en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.tox.2022.153311
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3271
dc.identifier.volume480en_US
dc.identifier.wosWOS:000901662900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiethylnitrosamineen_US
dc.subjectEumelaninen_US
dc.subjectHepatotoxicityen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleEumelanin protects the liver against diethylnitrosamine-induced liver injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu