Production of enantiomerically enriched chiral carbinols using Weissella paramesenteroides as a novel whole cell biocatalyst

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorTozlu, Caner
dc.contributor.authorŞahin, Engin
dc.contributor.authorSerencam, Hüseyin
dc.contributor.authorDertli, Enes
dc.date.accessioned2020-11-25T19:28:55Z
dc.date.available2020-11-25T19:28:55Z
dc.date.issued2019en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractIn this study, four bacterial strains were tested for their ability to reduce acetophenones to its corresponding alcohol. Among these strains Weissella paramesenteroides N7 was found to be the most successful biocatalyst to reduce the ketones to the corresponding alcohols. The reaction conditions were systematically optimized for W. paramesenteroides N7 that resulted in high enantioselectivity and conversion rates for the bioreduction. The scale-up asymmetric reduction of 1-(4-methoxyphenyl) propan-1-one (1r) by W. paramesenteroides N7 gave (R)-1-(4-methoxyphenyl) propan-1-ol (2r) with 94% yield and >99% enantiomeric excess. This is the first report showing the synthesis of (R)-1-(4-methoxyphenyl) propan-1-ol (2r) in enantiopure form using a biocatalyst on a gram scale. The whole cell catalyzed the reductions of ketone substrates on the preparative scale, demonstrating that W. paramesenteroides N7 would be a valuable biocatalyst for the preparation of chiral aromatic alcohols of pharmaceutical interest as a promising and alternative green approach. Weissella paramesenteroides as a food originated yeast species is capable of bioreduction of prochiral ketones to secondary chiral alcohols in one enantiomeric form.en_US
dc.identifier.citationTozlu, C., Şahin, E., Serencam, H., & Dertli, E. (2019). Production of enantiomerically enriched chiral carbinols using Weissella paramesenteroides as a novel whole cell biocatalyst. Biocatalysis and Biotransformation, 37(5), 388-398.en_US
dc.identifier.doi10.1080/10242422.2019.1568416
dc.identifier.endpage398en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85061243370en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10242422.2019.1568416?casa_token=YQcpHsrNtOsAAAAA%3AoJEw-OoJ36rF5eQ5zClN5PrhtQS-zAyGUR1_5KfBGqIezY8rlxpT_iYwTpqDxMXWxcRl9zkGYbZqlHQ
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2221
dc.identifier.volume37en_US
dc.identifier.wosWOS:000477723200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiocatalysis and Biotransformationen_US
dc.relation.ispartofBiocatalysis and Biotransformationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectWeissella paramesenteroides N7en_US
dc.subjectBiotransformationen_US
dc.subjectChiralityen_US
dc.titleProduction of enantiomerically enriched chiral carbinols using Weissella paramesenteroides as a novel whole cell biocatalysten_US
dc.typeArticleen_US

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