Inhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach.

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dc.authoridEmsen, Bugrahan/0000-0002-9636-2596
dc.contributor.authorEmsen, Bugrahan
dc.contributor.authorOzdemir, Ozlem
dc.contributor.authorEngin, Tubanur
dc.contributor.authorTogar, Basak
dc.contributor.authorCavusoglu, Seyda
dc.contributor.authorTurkez, Hasan
dc.date.accessioned2024-10-04T18:51:08Z
dc.date.available2024-10-04T18:51:08Z
dc.date.issued2019
dc.departmentBayburt Üniversitesien_US
dc.description.abstractHerbal medicines are efficient to reduce side effects in the fight against glioblastoma, which plays a critical role within brain cancer species. The recent studies designated for testing the effects of lichens that have shown numerous anticancer activities on glioblastoma so far. In the present study, different concentrations of water extract obtained from Usnea longissima Ach. were used in order to determine cytotoxic (via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase tests), antioxidant (via total antioxidant capacity test), pro-oxidant (via total oxidant status test) and genotoxic (via 8-hydroxy-2'-deoxyguanosine test) effects of them on human U87MG-glioblastoma cancer cell lines. Primary mixed glial-neuronal non-cancerous cells from Sprague-Dawley rats were also utilized to measure the effects of treatments on non-cancerous cells. Based on median inhibitory concentration values, the data belonged to non-cancerous cells (2486.71 mg/L) showed distinct towering compared to U87MG (80.93 mg/L) cells. The viability of non-cancerous and U87MG cells exposed to extract is decreased in a dose dependent manner. It was also showed that low concentrations of extract notably increased total antioxidant capacity on non-cancerous cells. In addition, various phenolic compounds in extract were detected through high-perfonnance liquid chromatography. The recent results encourage that extract will be able to have therapeutic potential against glioblastoma.en_US
dc.identifier.doi10.1590/0001-3765201920180994
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.issue3en_US
dc.identifier.pmid31596391en_US
dc.identifier.scopus2-s2.0-85073059205en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/0001-3765201920180994
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3397
dc.identifier.volume91en_US
dc.identifier.wosWOS:000493508900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Brasileira De Cienciasen_US
dc.relation.ispartofAnais Da Academia Brasileira De Cienciasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcytotoxicityen_US
dc.subjectgenotoxicityen_US
dc.subjectHPLCen_US
dc.subjecttotal antioxidant capacityen_US
dc.subjecttotal oxidative stressen_US
dc.titleInhibition of growth of U87MG human glioblastoma cells by Usnea longissima Ach.en_US
dc.typeArticleen_US

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