Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products

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dc.authorid54882270000
dc.authorid23502381000
dc.authorid23027537500
dc.authorid6701789599
dc.authorid6603903192
dc.authorid6603339039
dc.authorid14009507000
dc.contributor.authorBalaydiin H.T.
dc.contributor.authorSoyut H.
dc.contributor.authorEkinci D.
dc.contributor.authorGöksu S.
dc.contributor.authorBeydemir S.
dc.contributor.authorMenzek A.
dc.contributor.authorŞahin E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:40Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:40Z
dc.date.issued2012
dc.departmentBayburt Üniversitesien_US
dc.description.abstract(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl)methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new bromophenols. Inhibition of human cytosolic carbonic anhydrase II (hCA II) isozyme by these new bromophenols and naturally occurring 3,4,6-tribromo-5-(2,5- dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (3), and 5,5?-methylenebis(3, 4,6-tribromo-benzene-1,2-diol) (4) was investigated. The synthesized compounds showed carbonic anhydrase inhibitory capacities with IC 50 values in the range of 0.7372 ?M against hCA II. Some bromophenols investigated here showed effective hCA II inhibitory activity and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, or osteoporosis. © 2012 Informa UK, Ltd.en_US
dc.identifier.doi10.3109/14756366.2011.574131
dc.identifier.endpage50
dc.identifier.issn1475-6366
dc.identifier.issue1
dc.identifier.pmid21635211en_US
dc.identifier.scopus2-s2.0-79959914230en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage43
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2011.574131
dc.identifier.urihttps://hdl.handle.net/20.500.12403/909
dc.identifier.volume27
dc.identifier.wosWOS:000298748800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBromophenols
dc.subjectCarbonic anhydrase
dc.subjectDiphenylmethane
dc.subjectEnzyme inhibition
dc.subjectGlaucoma
dc.subject(2 bromo 3,4 dihydroxyphenyl)(2 bromo 4,5 dihydroxyphenyl)methanone
dc.subject(2 bromo 3,4 dihydroxyphenyl)(2,3 dibromo 4,5 dihydroxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(2 bromo 4,5 dimethoxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(2,3 dibromo 4,5 dimethoxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dihydroxyphenyl)(2,5 dibromo 3,4 dihydroxyphenyl)methanone
dc.subject(2 bromo 4,5 dihydroxyphenyl)(2,6 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dimethoxyphenyl)(2,5 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dimethoxyphenyl)(2,6 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject3,4,6 tribromo 5 (2,5 dibromo 3,4 dihydroxybenzyl)benzene 1,2 diol
dc.subject5,5' methylene bis(3,4,6 tribromo benzene 1,2 diol)
dc.subjectbromine derivative
dc.subjectbromophenol blue
dc.subjectcarbonate dehydratase II
dc.subjectcarbonate dehydratase inhibitor
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectbromination
dc.subjectcytosol
dc.subjectdemethylation
dc.subjectdrug synthesis
dc.subjectenzyme inhibition
dc.subjecthuman
dc.subjectIC 50
dc.subjectpriority journal
dc.subjectBenzophenones
dc.subjectBiological Agents
dc.subjectBromobenzenes
dc.subjectCarbonic Anhydrase II
dc.subjectCarbonic Anhydrase Inhibitors
dc.subjectCatechols
dc.subjectCytosol
dc.subjectDose-Response Relationship, Drug
dc.subjectHumans
dc.subjectIsoenzymes
dc.subjectMolecular Structure
dc.subjectStereoisomerism
dc.subjectStructure-Activity Relationship
dc.subjectBromophenols
dc.subjectCarbonic anhydrase
dc.subjectDiphenylmethane
dc.subjectEnzyme inhibition
dc.subjectGlaucoma
dc.subject(2 bromo 3,4 dihydroxyphenyl)(2 bromo 4,5 dihydroxyphenyl)methanone
dc.subject(2 bromo 3,4 dihydroxyphenyl)(2,3 dibromo 4,5 dihydroxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(2 bromo 4,5 dimethoxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(2,3 dibromo 4,5 dimethoxyphenyl)methanone
dc.subject(2 bromo 3,4 dimethoxyphenyl)(3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dihydroxyphenyl)(2,5 dibromo 3,4 dihydroxyphenyl)methanone
dc.subject(2 bromo 4,5 dihydroxyphenyl)(2,6 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dimethoxyphenyl)(2,5 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject(2 bromo 4,5 dimethoxyphenyl)(2,6 dibromo 3,4 dimethoxyphenyl)methanone
dc.subject3,4,6 tribromo 5 (2,5 dibromo 3,4 dihydroxybenzyl)benzene 1,2 diol
dc.subject5,5' methylene bis(3,4,6 tribromo benzene 1,2 diol)
dc.subjectbromine derivative
dc.subjectbromophenol blue
dc.subjectcarbonate dehydratase II
dc.subjectcarbonate dehydratase inhibitor
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectbromination
dc.subjectcytosol
dc.subjectdemethylation
dc.subjectdrug synthesis
dc.subjectenzyme inhibition
dc.subjecthuman
dc.subjectIC 50
dc.subjectpriority journal
dc.subjectBenzophenones
dc.subjectBiological Agents
dc.subjectBromobenzenes
dc.subjectCarbonic Anhydrase II
dc.subjectCarbonic Anhydrase Inhibitors
dc.subjectCatechols
dc.subjectCytosol
dc.subjectDose-Response Relationship, Drug
dc.subjectHumans
dc.subjectIsoenzymes
dc.subjectMolecular Structure
dc.subjectStereoisomerism
dc.subjectStructure-Activity Relationship
dc.titleSynthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural productsen_US
dc.typeArticleen_US

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