Does Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?

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dc.authorid0000-0001-6854-6059
dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorOzcan, Halil
dc.contributor.authorAydin, Pelin
dc.contributor.authorHalici, Zekai
dc.date.accessioned2026-02-28T12:18:10Z
dc.date.available2026-02-28T12:18:10Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractPurpose: This study aims to investigate Lrig1 expression and to reveal the possible relationship between Lrig1, ERBB1 and ERBB2 in schizophrenia. Materials and Methods: In this study, peripheral blood samples of 70 schizophrenia patients and 60 healthy controls were used. Real Time PCR was applied for Lrig1, ERBB1 and ERBB2 gene expression analysis. Results: The level of Lrig1 mRNA was lower in the patients when compared to healthy controls. Expression levels of ERBB1 and ERBB2 were decreased in the patients versus in the healthy controls. According to the receiver operating characteristic curve analysis, the three genes had the power to discriminate the patients from the ERBB1 and ERBB2 expressions in the patients. in schizophrenia.
dc.identifier.doi10.17826/cumj.1624159
dc.identifier.endpage230
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1
dc.identifier.startpage221
dc.identifier.trdizinid1308494
dc.identifier.urihttps://doi.org/10.17826/cumj.1624159
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1308494
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6137
dc.identifier.volume50
dc.identifier.wosWOS:001456063300023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectSchizophrenia
dc.subjectLrig1
dc.subjectERBB1
dc.subjectERBB2
dc.titleDoes Lrig1 expression have a relationship with ERBB1 and ERBB2 expression in schizophrenia?
dc.typeArticle

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