Microwave assisted green synthesis of nano-sized biogenic silver in extract of Phlomis linearis: potential anticancer and antimicrobial activities

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dc.contributor.authorOrcan Cayir, Ilayda
dc.contributor.authorTahta, Beyhan
dc.contributor.authorComertpay, Sabahattin
dc.contributor.authorUrus, Serhan
dc.contributor.authorBulbul, Ali Savas
dc.contributor.authorAygan, Ashabil
dc.contributor.authorAksan, Mehmet Emrah
dc.date.accessioned2026-09-01T15:52:37Z
dc.date.available2026-09-01T15:52:37Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractSilver nanoparticles (AgNPs) are known for their significant anticancer and antimicrobial activities in the field of medicine. In the present study, AgNPs were synthesized using a microwave-assisted green synthesis process, in which Ag(I) ions were reduced by organic compounds extracted from the leaves and stems of Phlomis linearis, an endemic plant which acted as both reducing and stabilizing agents. Although various species of the Phlomis genus have been studied in the literature, the synthesis of the nano-sized biogenic silver with reducing Ag(I) in the extract of the endemic plant P. linearis is reported here for the first study time, along with the evaluations of its bioactive properties. The obtained AgNPs were characterized by optical, structural, morphological, etc. techniques such as Ultraviolet-visible spectroscopy (UV-Vis.), Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), and photoluminescence (PL). Gas chromatography - mass spectrometry (GC-MS) and FT-IR techniques were used in order to evaluate the biochemical-reduction mechanism. When their antimicrobial activities were determined by the well diffusion method on six bacterial strains, the results showed that P. linearis exhibited antimicrobial activity against all tested bacteria. Additionally, the investigation of the anticancer activity of the particles by using the MTS method on a breast cancer cell line (MCF-7) and a healthy human cell population (human umbilical vein endothelial cells [HUVEC]) revealed that our AgNPs were more cytotoxic toward the cancerous cells compared to the non-cancerous ones (p < 0.001).[GRAPHICS]
dc.description.sponsorshipKahramanmarascedil; St Idot;mam University [2019/2-17 YLS, 2021/3-12 YLS] -- This work was financially supported by the Kahramanmara & scedil; Sutcu & Idot;mam University, The Coordination Unit of Scientific Research Projects (Project Number: 2021/3-12 YLS).
dc.identifier.doi10.1080/10426507.2026.2647301
dc.identifier.endpage1032
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue7
dc.identifier.orcid0000-0002-8002-252X
dc.identifier.scopus2-s2.0-105035406598
dc.identifier.scopusqualityQ3
dc.identifier.startpage1020
dc.identifier.urihttp://dx.doi.org/10.1080/10426507.2026.2647301
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8507
dc.identifier.volume201
dc.identifier.wosWOS:001737924500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPhosphorus Sulfur and Silicon and the Related Elements
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260820
dc.subjectBiogenic Silver
dc.subjectPhlomis Linearis
dc.subjectEndemic Plant
dc.subjectAntimicrobial
dc.subjectAnticancer
dc.subjectMicrowave-Assisted Synthesis
dc.titleMicrowave assisted green synthesis of nano-sized biogenic silver in extract of Phlomis linearis: potential anticancer and antimicrobial activities
dc.typeArticle

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