Investigation of antibacterial activities of copper based multinary sulfide alloys

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dc.authorid0000-0002-7672-2873
dc.authorid0000-0002-3935-9649
dc.contributor.authorKurt, Hacer
dc.contributor.authorCekceoglu, lknur Aksoy
dc.contributor.authorAcar, Eminegul Genc
dc.contributor.authorAslan, Emre
dc.contributor.authorOzel, Sultan Suleyman
dc.contributor.authorSarilmaz, Adem
dc.contributor.authorPatir, Imren Hatay
dc.date.accessioned2026-02-28T12:17:54Z
dc.date.available2026-02-28T12:17:54Z
dc.date.issued2024
dc.departmentBayburt Üniversitesi
dc.description.abstractOne of the nanomaterial-based antimicrobials, CuS, has emerged as a potential active therapeutic agent to combat biofilm infections, showing superior antibacterial activity with both photothermal and photodynamic effects under NIR illumination. To investigate the influence of transition metals on the antibacterial activity of CuxS, the antibacterial properties of shape- and phase- controlled copper-based multinary sulfide (M: CuxS (M: Mn, Zn and Ni)) nanostructures prepared by hot injection method were investigated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli under NIR light irradiation. It has been shown that CuxS-based nanomaterials suppress bacterial growth under NIR light irradiation and that, in addition to their antibacterial activity, they also exhibit a remarkable ability to form biofilms. The antibiofilm efficacy of the M: CuxS (M: Mn, Zn and Ni) nanocomposites was significantly higher than that of bare CuS, resulting in biofilm inhibition with rates of 52.53 %, 62.24 % and 74.48 % on E. coli for Mn:CuxS, Zn:CuxS and Ni:CuxS, respectively. In addition, the biofilm of S. aureus was more affected by treatment with M:CuxS (M: Mn, Zn and Ni) nano- composites, with biofilm activity of 64.15 %, 68.42 % and 87.35 % for Mn:CuxS, Zn:CuxS and Ni:CuxS, respectively. Ni:CuxS showed the highest antibacterial activity, which is attributed to smaller crystal and particle size and energy band gap, resulting in a larger number of nanoparticles per unit volume, a larger surface area and a stronger tendency to electrostatically bind to bacterial cell membranes, a faster ability to penetrate channels and stronger absorption in the NIR range. This work points the way for a broad application of CuS-based biocompatible synergistic antibacterial nanocomposites and can also serve as a guide for antibacterial/antibiofilm approaches as an alternative to conventional antibiotic treatments.
dc.description.sponsorshipResearch Foundation of Selcuk University (SUBAP) [23201020]
dc.description.sponsorshipThe authors would like to thank Research Foundation of Selcuk University (SUBAP- Grant No: 23201020) for financial support of this work. This paper is the part of M.Sc. thesis prepared by Hacer Kurt.
dc.identifier.doi10.1016/j.jece.2024.114912
dc.identifier.issn2213-2929
dc.identifier.issn2213-3437
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85210314083
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jece.2024.114912
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6001
dc.identifier.volume12
dc.identifier.wosWOS:001371541500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofJournal of Environmental Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260218
dc.subjectAntibacterial activity
dc.subjectAntibiofilm activity
dc.subjectCopper sulfide
dc.subjectNear infrared light
dc.titleInvestigation of antibacterial activities of copper based multinary sulfide alloys
dc.typeArticle

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