OPIOIDERGIC SYSTEM-MEDIATED ANTINOCICEPTIVE ACTIVITY OF TOFISOPAM

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dc.contributor.authorTuran Yücel, Nazlı
dc.contributor.authorÜçel, Umut İrfan
dc.contributor.authorYazici, Cevşen
dc.contributor.authorDemi?R Özkay, Ümide
dc.contributor.authorCan, Özgür Devrim
dc.date.accessioned2024-10-04T18:58:45Z
dc.date.available2024-10-04T18:58:45Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractObjective: In this study, it was aimed to investigate antinociceptive activity potential of Tofisopam and to elucidate the possible involvement of opioid system in this effect. Material and Method: The antinociceptive efficacy potential of Tofisopam (25 and 50 mg/kg) was evaluated by hot-plate and acetic acid-induced writhing tests; while possible effects of this drug on the motor coordinations of mice were evaluated with the Rota-rod tests. Result and Discussion: Tofisopam at a dose of 50 mg/kg significantly prolonged the reaction times of mice in hot-plate tests and reduced the number of writhing behaviors in writhing tests. These findings indicated that Tofisopam has antinociceptive activity mediated by central and peripheral mechanisms. Tofisopam did not change the motor activities of mice at administrated doses. Pre-administration of naloxone to investigate the possible involvement of opioid receptors in the antinociceptive effect abolished the antinociceptive activity of Tofisopam. To elucidate the opioid receptor subtypes mediating the effect, mechanistic studies were carried out with naloxonazine (?-opioid receptor blocker), naltrindole (?-opioid receptor blocker), and norbinaltorphimine (?-opioid receptor blocker). All agents antagonized the antinociceptive effect of Tofisopam. Obtained findings revealed that Tofisopam at a dose of 50 mg/kg has antinociceptive activity mediated by ?-, ?- and ?-opioid receptors. © 2022 Authors. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1085314
dc.identifier.endpage727en_US
dc.identifier.issn2564-6524
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85149975386en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage712en_US
dc.identifier.trdizinid1135046en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1085314
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1135046
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4017
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetic acid-induced writhing testen_US
dc.subjectAnalgesiaen_US
dc.subjecthot-plate testen_US
dc.subjectopioidergic receptoren_US
dc.subjecttofisopamen_US
dc.titleOPIOIDERGIC SYSTEM-MEDIATED ANTINOCICEPTIVE ACTIVITY OF TOFISOPAMen_US
dc.title.alternativeTOFİSOPAM’IN OPİOİDERJİK SİSTEM ARACILIKLI ANTİNOSİSEPTİF ETKİNLİĞİen_US
dc.typeArticleen_US

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