Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats

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dc.authoridSait, Ahmet/0000-0001-7658-8793
dc.authoridGUVEN, LEYLA/0000-0002-3189-6415
dc.contributor.authorGul, Sema Nur Sevinc
dc.contributor.authorEminoglu, Didem Ozkal
dc.contributor.authorTekce, Emre
dc.contributor.authorBayraktar, Bulent
dc.contributor.authorGuven, Leyla
dc.contributor.authorDilsiz, Alparslan
dc.contributor.authorYildrim, Serkan
dc.date.accessioned2024-10-04T18:49:44Z
dc.date.available2024-10-04T18:49:44Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractA chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-alpha, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-alpha, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNFa, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process. (c) 2024 SAAB. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.en_US
dc.description.sponsorshipAtaturk University Scientific Research Projects Coordinator [2022-11995]en_US
dc.description.sponsorshipThe authors report no conflict of interest related to this study. This study was supported by the Ataturk University Scientific Research Projects Coordinator (project no: 2022-11995) . Therefore, we are grateful to the Ataturk University, Turkey.en_US
dc.identifier.doi10.1016/j.sajb.2024.07.049
dc.identifier.endpage585en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85200322193en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2024.07.049
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3270
dc.identifier.volume172en_US
dc.identifier.wosWOS:001291272800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEugenolen_US
dc.subjectExperimental periodontitisen_US
dc.subjectIL-6en_US
dc.subjectTNF-aen_US
dc.subjectLeptinen_US
dc.subjectAsprosinen_US
dc.subjectApelinen_US
dc.titleEugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in ratsen_US
dc.typeArticleen_US

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