Virucidal and antiviral activities of maca (Lepidium meyenii) root powder on three pathways of Norovirus as a foodborne pathogen

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dc.contributor.authorKorkmaz, Irem Omurtag
dc.contributor.authorKorkmaz, Serol
dc.contributor.authorParmasiz, Ayse
dc.contributor.authorMavili, Seda
dc.contributor.authorBayraktar, Bulent
dc.contributor.authorSait, Ahmet
dc.contributor.authorKeles, Aysen Gargili
dc.date.accessioned2026-09-01T15:52:35Z
dc.date.available2026-09-01T15:52:35Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractVitamin C equivalency, the cytotoxicity on murine macrophage cells, and the virucidal and antiviral activities of maca (Lepidium meyenii) powder on murine norovirus (MNV) as a norovirus surrogate for human as a foodborne pathogen were studied. The antioxidant capacity of the maca was determined by MTT assay as vitamin C equivalency (VCEAC). The 50% cytotoxic concentration (CC50) was calculated with the linearity of maca concentrations-cell viability. The activities of maca against the virus was determined as the 50% tissue culture infective dose with Spearman-Karber method. The VCEAC of maca linearly increased with the concentration. The non-cytotoxic concentrations of maca were measured on murine macrophage with a CC50 of 5.77 mg/mL and a CC80 of 1.28 mg/mL. As maca reduced the virus titration based on contact time in the virucidal assay in several conditions, it did not significantly inhibit MNV on three infectivity pathways of host cell at non-cytotoxic concentrations of maca. The result of this first study presented that despite its ineffective in the treatment and prophylaxis of norovirus infection, maca might be an alternative food additive and preservative against human norovirus as an important foodborne pathogen causing outbreaks worldwide.
dc.identifier.doi10.15381/rivep.v37i2.30727
dc.identifier.issn1682-3419
dc.identifier.issn1609-9117
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105043301267
dc.identifier.scopusqualityQ4
dc.identifier.urihttp://dx.doi.org/10.15381/rivep.v37i2.30727
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8472
dc.identifier.volume37
dc.identifier.wosWOS:001825434000029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Nacional Mayor San Marcos
dc.relation.ispartofRevista de Investigaciones Veterinarias Del Peru
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260820
dc.subjectLepidium Meyenii
dc.subjectMaca
dc.subjectNorovirus
dc.subjectAntiviral
dc.subjectFood Safety
dc.titleVirucidal and antiviral activities of maca (Lepidium meyenii) root powder on three pathways of Norovirus as a foodborne pathogen
dc.typeArticle

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