Bioactive compounds of deep eutectic solvents extracts of Hypericum perforatum L.: Polyphenolic- organic acid profile by LC-MS/MS and pharmaceutical activity

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dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.contributor.authorBayram, Sinan
dc.contributor.authorKutlu, Naciye
dc.contributor.authorGercek, Yusuf Can
dc.contributor.authorCelik, Saffet
dc.contributor.authorBayram, Nesrin Ecem
dc.date.accessioned2024-10-04T18:48:24Z
dc.date.available2024-10-04T18:48:24Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractDeep eutectic solvents (DESs) are known as environmentally-friendly solvents that have emerged as an alter-native to conventional organic solvents in recent years. In this study, the effects of ten different DESs on the extraction of bioactive components from the Hypericum perforatum were investigated. Total phenolic content, total flavonoid content, phenolic profile (32 phenolics), organic acid profile (52 organic acids), as well as antioxidant and antimicrobial activities of H. perforatum extracts prepared using DESs and ultrasonic-assisted extraction method were determined. Total phenolic, total flavonoid content, and antioxidant activities of ex-tracts were determined between 3.10 +/- 0.86-16.64 +/- 2.09 mg GA/g, 0.02 +/- 0.00-12.29 +/- 0.30 mg QE/g, and 8.40 +/- 0.50-44.78 +/- 2.66 mg TE/g, respectively. DES2 (choline chloride:ethylene glycol) and DES7 (choline chloride:lactic acid) demonstrated higher extraction success than other DESs for extracting phenolics and organic acids, respectively. DESs prepared using organic acid as hydrogen bond donor were found to have an antibacterial effect against all bacterial samples. However, the inhibitory effect against yeast-like fungi was observed in a narrower spectrum. Moreover, the results from principal component analysis also confirmed that the type of solvent used for extraction has a significant influence on the phenolics, organic acid, and other parameters. As a result, it was seen that DES components directly affect the extraction efficiency of target compounds from H. perforatum. This is a first and original report about use of DESs in extracting different bioactive components from H. perforatum.en_US
dc.description.sponsorshipBayburt University, Turkey; Scien- tific Research Projects Commission [2021/69001- 01-09]en_US
dc.description.sponsorshipThis research was supported by Bayburt University, Turkey; Scien- tific Research Projects Commission with project number 2021/69001- 01-09 .en_US
dc.identifier.doi10.1016/j.fbio.2022.101926
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85136298624en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2022.101926
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3045
dc.identifier.volume49en_US
dc.identifier.wosWOS:000863167900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeep eutectic solvent (DES)en_US
dc.subjectGreen technologyen_US
dc.subjectAntimicrobial activityen_US
dc.subjectPhenolic profileen_US
dc.subjectAntioxidant activityen_US
dc.subjectOrganic aciden_US
dc.titleBioactive compounds of deep eutectic solvents extracts of Hypericum perforatum L.: Polyphenolic- organic acid profile by LC-MS/MS and pharmaceutical activityen_US
dc.typeArticleen_US

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