Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines

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dc.authorid56483312800
dc.authorid56483004700
dc.authorid56483295600
dc.contributor.authorSaygide?er Demir B.
dc.contributor.authorKeleş T.
dc.contributor.authorSerinda? O.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:08Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:08Z
dc.date.issued2014
dc.departmentBayburt Üniversitesien_US
dc.description.abstractPhosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines { [PdCl2((CH2OH)CH2)CH3] (C1), [RuCl2(((CH2OH)CH2)CH3) (C2), [PtCl2((Ph2PCH2)CH3)(timin) (C3) } on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells. © 2014 Burcu Saygide?er Demir et al.en_US
dc.identifier.doi10.1155/2014/717421
dc.identifier.issn1565-3633
dc.identifier.pmid25610346en_US
dc.identifier.scopus2-s2.0-84921038696en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2014/717421
dc.identifier.urihttps://hdl.handle.net/20.500.12403/778
dc.identifier.volume2014
dc.identifier.wosWOS:000347828700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBioinorganic Chemistry and Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell linesen_US
dc.typeArticleen_US

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