Antioxidant effect of Rosa pimpinellifolia L. fruit extract on cholestatic liver injury: an experimental study

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dc.authoridyazici, pinar/0000-0002-3445-5084
dc.authoridYazici Ozkaya, Pinar/0000-0002-1209-2534
dc.authoridDEMIRCIOGLU, ZEYNEP GUL/0000-0002-9331-0897
dc.authoridDemircioglu, Mahmut Kaan/0000-0002-4652-7655
dc.contributor.authorDemircioglu, Mahmut Kaan
dc.contributor.authorDemircioglu, Zeynep Gul
dc.contributor.authorCakir, Ozlem
dc.contributor.authorYanar, Karolin
dc.contributor.authorOzguven, Muveddet Banu Yilmaz
dc.contributor.authorAtukeren, Pinar
dc.contributor.authorGulcicek, Osman Bilgin
dc.date.accessioned2024-10-04T18:48:16Z
dc.date.available2024-10-04T18:48:16Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBACKGROUND: Antioxidants have been considered a rational curative strategy to prevent and cure liver diseases involving oxidative stress. An acute obstructive jaundice rat model was established to investigate the in vivo hepatoprotective efficacy of Rosa pimpinellifolia L.METHODS: The experimental jaundice model was performed by binding the main bile duct in 25 male Sprague-Dawley rats. All rats were randomly divided into five groups: first group: laparotomy-sham-only, second group: biliary tract binding (control), and third, fourth, and fifth groups: treatment groups with 250, 500, and 750 mg/kg fruit extracts daily, respectively.RESULTS: Considering dosage, although there was no significant therapeutic effect in the 250 mg/kg of Rosa pimpinellifolia L. group, the best results were found in the 500 mg/kg dose group, while results in the 750 mg/kg dose group showed consistent correlation with proinflammatory response. With regard to biochemical parameters, lipid hydroperoxide level in the rat serum and liver tissue was significantly decreased in all treatment groups. Amadori products, which are one of the early markers of glycol-oxidative stress, showed statistical significance in the treatment.CONCLUSION: It was revealed that the antioxidant effect of Rosa pimpinellifolia L. was more prominent in the early stages of hepatic injury secondary to oxidative stress.en_US
dc.description.sponsorshipScientific Research Project Unit of the University of Health Sciences [2019/103]en_US
dc.description.sponsorshipThis experimental study was supported by the Scientific Research Project Unit of the University of Health Sciences (Project Number: 2019/103, Ethics Approval number: 2019/223) .en_US
dc.identifier.doi10.1590/1806-9282.20230720
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue1en_US
dc.identifier.pmid38198394en_US
dc.identifier.scopus2-s2.0-85182098825en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20230720
dc.identifier.urihttp://hdl.handle.net/20.500.12403/2998
dc.identifier.volume70en_US
dc.identifier.wosWOS:001143864800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholestasis. Liveren_US
dc.subjectAntioxidantsen_US
dc.subjectRosaceaeen_US
dc.titleAntioxidant effect of Rosa pimpinellifolia L. fruit extract on cholestatic liver injury: an experimental studyen_US
dc.typeArticleen_US

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