Partial characterization of a levan type exopolysaccharide (EPS) produced by Leuconostoc mesenteroides showing immunostimulatory and antioxidant activities

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dc.authoridTaylan, Osman/0000-0002-5806-3237
dc.contributor.authorTaylan, Osman
dc.contributor.authorYilmaz, Mustafa Tahsin
dc.contributor.authorDertli, Enes
dc.date.accessioned2024-10-04T18:52:36Z
dc.date.available2024-10-04T18:52:36Z
dc.date.issued2019
dc.departmentBayburt Üniversitesien_US
dc.description.abstractLeuconostoc mesenteroides S81 was isolated from traditional sourdough as an exopolysaccharide (EPS) producer strain. The monosaccharide composition of the EPS from strain S81 was characterized by HPLC analysis and only fructose was found in the repeating unit structure. The NMR spectroscopy analysis revealed that EPS was a levan type EPS as a beta-(2 -> 6)-linked fructan. The MR analysis further confirmed the presence of the furanoid rings in the EPS structure. The levan S81 showed high level of thermal stability determined by DSC and TGA analysis. The lyophilised levan S81 showed a sheet-like compact morphology and its aqueous solution formed spheroidal lumps with a compact structure detected by SEM and AFM analysis, respectively. Importantly the levan S81 showed a high level of immunomodulatory role, induced the anti-inflammatory cytokine IL-4, and exhibited a strong antioxidant capacity with EC50 value 1.7 mg mL(-1) obtained by hydroxyl radical scavenging activity test under in vitro conditions. These findings reveal potential of levan S81 for technological purposes and as a potential natural immunomodulatory and antioxidant. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDeanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [D-181-135-1439]en_US
dc.description.sponsorshipThis work was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant No. (D-181-135-1439). The authors, therefore, gratefully acknowledge the DSR technical and financial support.en_US
dc.identifier.doi10.1016/j.ijbiomac.2019.06.078
dc.identifier.endpage444en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid31201910en_US
dc.identifier.scopus2-s2.0-85067452472en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.06.078
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3579
dc.identifier.volume136en_US
dc.identifier.wosWOS:000482533000044en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLevanen_US
dc.subjectLeuconostoc mesenteroidesen_US
dc.subjectImmune modulationen_US
dc.subjectPhysicochemical characteristicsen_US
dc.subjectAntioxidanten_US
dc.titlePartial characterization of a levan type exopolysaccharide (EPS) produced by Leuconostoc mesenteroides showing immunostimulatory and antioxidant activitiesen_US
dc.typeArticleen_US

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