Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance

Basit Öğe Kaydı
dc.authoridBayat, Ramazan/0000-0002-9763-1591
dc.authoridKarimi-Maleh, Hassan/0000-0002-1027-481X
dc.authoridBurhan, Hakan/0000-0002-2293-7369
dc.authoridkocabas, yusuf ziya/0000-0003-2831-8910
dc.contributor.authorBostanci, Maside Temiz
dc.contributor.authorBulbul, Ali Savas
dc.contributor.authorCelik, Ibrahim Seyfettin
dc.contributor.authorKocabas, Yusuf Ziya
dc.contributor.authorBurhan, Hakan
dc.contributor.authorBayat, Ramazan
dc.contributor.authorSen, Fatih
dc.date.accessioned2024-10-04T18:51:10Z
dc.date.available2024-10-04T18:51:10Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIn this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 bacteria and 2 fungi of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth species were performed by Agar Well Diffusion and Microdilution methods. Salvia species showed sensitivity with a zone diameter of 12-16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the dilution method were used to determine the Minimum inhibited concentration (MIC) and Minimum bactericidal concentration (MBK). The MIC values of the plants are mostly 0.5 mg/ml- 4 mg/ml and MBC values are between 0.5 mg/ml- 8 mg/ml. Antifungal activity findings are remarkable on the species and it has been observed to have very high effects especially on Candida parapsilosis. When the antioxidant research findings are examined; It was observed that Salvia marashica and Salvia caespitosa plants have approximately 75% antioxidant activity at 1 mg/ml, and findings mostly directly proportional be- tween concentrations and antioxidant activity capacity were recorded. MCF-7 and HUVEC cell lines were used to investigate anticancer activity properties. In line with the findings, while the IC50 value of Salvia marashica on the MCF-7 Cell line was 0.125 mg/ml, it was 1.65 mg/ml in the HUVEC cell line, while the IC50 value of Salvia caespitosa on the MCF-7 Cell line was 0.115 mg/ml in the HUVEC Cell line. It was found to be 9.87 mg/ml. It has been proven that both Salvia species have a cytotoxic effect on the MCF-7 Cell line.en_US
dc.description.sponsorshipscientific research projects unit of Kahramanmaras Sutcu Imam University (BAP Project) [2020/6-3]; Dumlupinar University [2014-05]en_US
dc.description.sponsorshipThis study was supported within the scope of the project by the scientific research projects unit of Kahramanmaras Sutcu Imam University (BAP Project 2020/6-3) . The authors also would like to thank to Dumlupinar University for funding (2014-05)en_US
dc.identifier.doi10.1016/j.chemosphere.2021.132602
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.pmid34673041en_US
dc.identifier.scopus2-s2.0-85118356592en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2021.132602
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3414
dc.identifier.volume288en_US
dc.identifier.wosWOS:000754685500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofChemosphereen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectMCF-7en_US
dc.subjectHUVECen_US
dc.subjectSalvia speciesen_US
dc.subjectAntibiofilmen_US
dc.titleInvestigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importanceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu