Chemical Profiling and Biological Activities of Methanol Extracts and Essential Oils from Ferulago platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties

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dc.contributor.authorAygul, Imdat
dc.contributor.authorOz, Mehmet
dc.contributor.authorFidan, Muhammed Said
dc.contributor.authorAkmee, Cemalettin Baltaci Osman
dc.contributor.authorAkmese, Osman
dc.contributor.authorSefali, Abdurrahman
dc.date.accessioned2026-02-28T12:18:09Z
dc.date.available2026-02-28T12:18:09Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractThis study aimed to evaluate the phytochemical composition and biological activities of Ferulago platycarpa methanol extract (ME) and essential oil (EO). The EO was obtained via hydrodistillation and analyzed by GC-MS, revealing sesquiterpene hydrocarbons as the dominant class, with caryophyllene (65.8%) and a-pinene (9.65%) as the major constituents. The methanol extract was subjected to LC-MS/MS analysis, which identified eleven phenolic compounds, with chlorogenic acid as the most abundant. The extract showed significantly higher total phenolic (1196.22 +/- 11.64 mg GAE/100g) and antioxidant (1870.00 +/- 17.69 mg QEE/100g) contents compared to the ME. In vitro enzyme inhibition assays demonstrated that the methanol extract exhibited potent inhibitory activity against carbonic IC50=110 mu g/mL), and butyrylcholinesterase (BChE, IC50=390 mu g/mL). In contrast, the EO showed higher inhibition against a-amylase (IC50=5920 +/- 10.45 mu g/mL) and BChE (IC50=1.32 +/- 0.65 mu g/mL), while its aglucosidase showed no inhibition. Antioxidant assays indicated superior activity for the methanol extract compared to the EO. Furthermore, antimicrobial testing revealed that the EO demonstrated broader and more effective antimicrobial action, exhibiting lower MIC and MBC values against several bacterial and fungal strains. Collectively, these results highlight F. platycarpa as a valuable source of bioactive compounds with promising applications in antidiabetic, neuroprotective, antioxidant, and antimicrobial therapies.
dc.identifier.doi10.15376/biores.21.1.1110-1139
dc.identifier.endpage1139
dc.identifier.issn1930-2126
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105026839141
dc.identifier.scopusqualityQ3
dc.identifier.startpage1110
dc.identifier.urihttps://doi.org/10.15376/biores.21.1.1110-1139
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6123
dc.identifier.volume21
dc.identifier.wosWOS:001671742800031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNorth Carolina State Univ Dept Wood & Paper Sci
dc.relation.ispartofBioresources
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectFerulago platycarpa Boiss. & Balansa
dc.subjectEssential oil
dc.subjectAntioxidant and antimicrobial activities
dc.subjectGC-114S/FID
dc.titleChemical Profiling and Biological Activities of Methanol Extracts and Essential Oils from Ferulago platycarpa Boiss. & Balansa (Endemic): Enzyme Inhibition, Antioxidant, and Antimicrobial Properties
dc.typeReview Article

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