Diagnostic and Prognostic Significance of miR-155, miR-181, miR-221, miR-222, and miR-223 Expression in Myelodysplastic Syndromes and Acute Myeloid Leukemia

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dc.authorid0000-0002-6191-2930
dc.authorid0000-0002-6493-3403
dc.authorid0009-0002-5330-8554
dc.authorid0000-0003-2108-1316
dc.authorid0000-0002-7109-5540
dc.contributor.authorArdic, Cemile
dc.contributor.authorAy, Mustafa Ertan
dc.contributor.authorCevik, Kenan
dc.contributor.authorTombak, Anil
dc.contributor.authorIzci Ay, Ozlem
dc.contributor.authorKarakas, Umit
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2026-02-28T12:18:15Z
dc.date.available2026-02-28T12:18:15Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: Myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) are clonal hematological disorders that share molecular origins but present with distinct clinical features. MicroRNAs (miRNAs) are key post-transcriptional regulators, and their altered expression may reflect biological shifts contributing to disease progression. Methods: Expression levels of miR-155, miR-181, miR-221, miR-222, and miR-223 were analyzed by RT-qPCR in bone marrow samples from 37 MDS patients, 20 AML patients, and 7 controls. Group comparisons were performed using ANOVA (with Benjamini-Hochberg correction) and Tukey post hoc testing. Diagnostic performance and network behavior were evaluated using ROC analysis, Pearson correlation matrices, and principal component analysis (PCA). Results: miR-155, miR-181, and miR-223 were upregulated in AML, whereas miR-221 and miR-222 were downregulated. miR-222 showed the highest diagnostic accuracy (AUC similar to 0.87 for both AML vs. control and MDS vs. control). Its expression was significantly higher in high IPSS-R MDS cases (p = 0.046), with a similar upward tendency for miR-221 (p = 0.054). Progressive loss of coordinated miRNA expression was observed from controls to MDS and AML. PCA supported these findings by showing separation mainly driven by miR-222 and miR-155. Conclusions: Combined miRNA profiling highlights miR-222 and, to a lesser extent miR-155, as consistent indicators of myeloid disease transformation. While further validation in larger and genetically stratified cohorts is warranted, these findings support the potential contribution of miRNA signatures to diagnostic evaluation and risk stratification in MDS and AML, in line with precision hematology approaches.
dc.description.sponsorshipMersin University Scientific Research Projects Coordination Unit. [2017-1-TP2-2037]
dc.description.sponsorshipThis study is supported by the Mersin University Scientific Research Projects Coordination Unit. Project Number: 2017-1-TP2-2037.
dc.identifier.doi10.3390/diagnostics16010013
dc.identifier.issn2075-4418
dc.identifier.issue1
dc.identifier.pmid41515508
dc.identifier.scopus2-s2.0-105027239822
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/diagnostics16010013
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6186
dc.identifier.volume16
dc.identifier.wosWOS:001658679800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectmyelodysplastic syndrome
dc.subjectacute myeloid leukemia
dc.subjectmiR-155
dc.subjectmiR-181
dc.subjectmiR-221
dc.subjectmiR-222
dc.subjectmiR-223
dc.subjectbiomarker
dc.titleDiagnostic and Prognostic Significance of miR-155, miR-181, miR-221, miR-222, and miR-223 Expression in Myelodysplastic Syndromes and Acute Myeloid Leukemia
dc.typeArticle

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