Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs

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dc.contributor.authorKotan, Goksad Cemil
dc.contributor.authorBayraktar, Bulent
dc.date.accessioned2026-09-01T15:52:35Z
dc.date.available2026-09-01T15:52:35Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground This study investigated the effects of dietary graviola (Annona muricata L.) oil extract (GOE) (supplemented at 200, 400, and 600 mg/kg) on the growth performance and circadian rhythm profiles of adipokine, cardiac, and mitochondrial function biomarkers in 48 male Anatolian Merino lambs (2.5 months old). Methods Lambs were assigned to a control group (G0) or supplementation groups (G200, G400, G600 mg/kg) for a 60-day trial (70 days total). The study was conducted under a 12-h light/12-h dark cycle to ensure controlled environmental conditions. To analyze circadian profiles, blood samples were collected on days 0, 15, 30, 45, and 60 at four time points (07:00, 13:00, 19:00, and 01:00). Serum levels of Apelin, cTnI, BMAL1, MOTS-c, and BMCP1 were measured by ELISA. Data were analyzed using GLM Multivariate analysis (p < 0.05). Results Key findings showed the G400 dose resulted in the most effective linear increase in live weight and live weight gain by day 60, and had a significant overall effect on live weight (p < 0.05). The G200 dose significantly improved the feed conversion ratio (p < 0.05), while feed consumption was unaffected (p > 0.05). Regarding biomarkers on day 60, the G400 dose effectively modulated BMAL1, MOTS-c, and BMCP1 (peak at 19:00). The G600 dose yielded the best results for Apelin (peak at 19:00) and cTnI (peaks at 13:00 and 07:00). Conclusions In conclusion, GOE at a dose of 400 mg/kg (G400) not only optimizes fattening performance in Anatolian Merino lambs but also supports metabolic homeostasis by modulating adipokine levels, cardiac function, and mitochondrial biogenesis processes in a manner consistent with the circadian rhythm. These findings demonstrate that the G400 dose is a safe and effective phytogenic strategy for improving animal health and production efficiency.
dc.identifier.doi10.1186/s12917-026-05400-3
dc.identifier.issn1746-6148
dc.identifier.issue1
dc.identifier.pmid41803858
dc.identifier.scopus2-s2.0-105035880501
dc.identifier.scopusqualityN/A
dc.identifier.urihttp://dx.doi.org/10.1186/s12917-026-05400-3
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8483
dc.identifier.volume22
dc.identifier.wosWOS:001742601200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBmc Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260820
dc.subjectCircadian Rhythm
dc.subjectApelin
dc.subjectCardiac Troponin I (Ctni)
dc.subjectBrain And Muscle Arnt-Like Protein 1 (Bmal1) And Mitochondrial Function
dc.subjectMitochondrial-Derived Peptide (Mots-C)
dc.subjectBrain Mitochondrial Carrier Protein-1 (Bmcp1)
dc.subjectGraviola
dc.subjectLamb
dc.titleEffects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs
dc.typeArticle

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