BENEFICIAL EFFECTS OF REBOXETINE ON IMPAIRED BEHAVIORAL PARAMETERS OF DIABETIC RATS

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dc.contributor.authorTuran Yücel, Nazli
dc.contributor.authorKandemir, Ümmühan
dc.contributor.authorÜçel, Umut Irfan
dc.contributor.authorCan, Özgür Devrim
dc.contributor.authorDemir Özkay, Ümide
dc.date.accessioned2024-10-04T18:58:37Z
dc.date.available2024-10-04T18:58:37Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractObjective: The incidence of emotional and cognitive disorders are higher in diabetic patients with respect to the general population. In this study, it was aimed to investigate the efficacy of reboxetine, a clinically prescribed drug for its antidepressant effect, on behavioral and cognitive alterations caused by diabetes in rats. Material and Method: An experimental diabetes model in rats was induced with a single 50 mg/kg injection of streptozotocin (i.v.). Reboxetine treatment was started 4 weeks after induction of diabetes in order to observe diabetic complications. Depression and anxiety levels of experimental animals were investigated by modified forced swimming and elevated plus-maze tests, respectively; cognitive performances were evaluated by Morris water-maze and passive avoidance experiments. The motor activities of the animals were also examined with the activity cage and Rota-rod tests. Result and Discussion: Obtained results indicated that the depression and anxiety levels of diabetic rats were increased and their cognitive performances were weakened. Reboxetine treatment (8 and 16 mg/kg) for two weeks reduced the elevated depression and anxiety levels in diabetic rats, while significantly improving their weakened cognitive performance. The findings indicated that reboxetine might possess a therapeutic potential for the cure of behavioral and cognitive impairements concomitant with diabetes. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1149796
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85145463430en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.trdizinid1155464en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1149796
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1155464
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3920
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnxietyen_US
dc.subjectcognitionen_US
dc.subjectdepressionen_US
dc.subjectDiabetes mellitusen_US
dc.subjectreboxetineen_US
dc.titleBENEFICIAL EFFECTS OF REBOXETINE ON IMPAIRED BEHAVIORAL PARAMETERS OF DIABETIC RATSen_US
dc.title.alternativeREBOKSETİN'İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİen_US
dc.typeArticleen_US

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