Synthesis of flaxseed gum/melanin-based scaffold: A novel approach for nano-encapsulation of doxorubicin with enhanced anticancer activity

Basit Öğe Kaydı
dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.contributor.authorKumar, Deepak
dc.contributor.authorPal, Ravi Raj
dc.contributor.authorDas, Neeladri
dc.contributor.authorRoy, Partha
dc.contributor.authorSaraf, Shubhini A.
dc.contributor.authorBayram, Sinan
dc.contributor.authorKundu, Patit P.
dc.date.accessioned2024-10-04T18:53:49Z
dc.date.available2024-10-04T18:53:49Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractDoxorubicin is a powerful chemotherapy medicine that is frequently used to treat cancer, but because of its extremely destructive side effects on other healthy cells, its applications have been severely constrained. With the aim of using lower therapeutic doses of doxorubicin while maintaining the same anti-cancerous activity as those of higher doses, the present study designs nano-encapsulation of doxorubicin by acrylamide grafted melanin as core and acrylic acid grafted flax seed gum as shell (DOX@AAM-g-ML/AA-g-FSG-NPs) for studies in-vivo and in vitro anticancer activity. For biological studies, the cytotoxicity of DOX@AAM-g-ML/AA-g-FSG-NPs was examined on a cancerous human cell line (HCT-15) and it was observed that DOX@AAM-g-ML/AA-g-FSG-NPs exhibited very high toxicity towards HCT-15. In-vivo investigation in colon cancer-inflicted rat model also showed that DOX@AAM-g-ML/AA-g-FSG-NPs showed better anticancer activity against cancerous cells as compared to free doxorubicin. The drug release behavior of DOX@GML-GFS-NPs was studied at several pH and maximum drug release (95 %) was recorded at pH-7.2, and kinetic data of drug release was follows the Higuchi (R2 = 0.9706) kinetic model. Our study is focussed on reducing the side effects of doxorubicin by its nano encapsulation in acrylamide grafted melanin as core and acrylic acid grafted flax seed gum that will also enhance its efficiency.en_US
dc.description.sponsorshipIIT Roorkeeen_US
dc.description.sponsorshipDeepak Kumar is thankful to IIT Roorkee, for financial assistance and characterization of samples.en_US
dc.identifier.doi10.1016/j.ijbiomac.2023.127964
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid37951423en_US
dc.identifier.scopus2-s2.0-85178420691en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.127964
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3724
dc.identifier.volume256en_US
dc.identifier.wosWOS:001129813900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectGrafted melaninen_US
dc.subjectFlaxseed gumen_US
dc.subjectDrug deliveryen_US
dc.subjectCore shell nanoparticleen_US
dc.subjectAnti-canceren_US
dc.titleSynthesis of flaxseed gum/melanin-based scaffold: A novel approach for nano-encapsulation of doxorubicin with enhanced anticancer activityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu