Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

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dc.authoridBOLAT, ISMAIL/0000-0003-1398-7046
dc.authoridGolokhvast, Kirill/0000-0002-4873-2281
dc.authoridYILDIRIM, Serkan/0000-0003-2457-3367
dc.authoridTSATSAKIS, ARISTIDIS/0000-0003-3824-2462
dc.contributor.authorSevim, Cigdem
dc.contributor.authorAkpinar, Erol
dc.contributor.authorAksu, Emrah Hicazi
dc.contributor.authorOmur, Ali Dogan
dc.contributor.authorYildirim, Serkan
dc.contributor.authorKara, Mehtap
dc.contributor.authorBolat, Ismail
dc.date.accessioned2024-10-04T18:52:49Z
dc.date.available2024-10-04T18:52:49Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2 '-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.en_US
dc.description.sponsorshipAtaturk University Scientific Research Project department (BAPSIS) [TDK-2018-6537]; European Union; Russian Federation; [?220-2961-3099]en_US
dc.description.sponsorshipThis research was funded by Ataturk University Scientific Research Project department (BAPSIS) and project code TDK-2018-6537 and the project was partially funded by the European Union's Horizon Europe framework program project name: European Partnership for the Assessment of Risks from Chemicals (PARC) and supported by the Decree No. 220 of the Russian Federation (Mega-grant ?220-2961-3099).en_US
dc.identifier.doi10.3390/toxics11020170
dc.identifier.issn2305-6304
dc.identifier.issue2en_US
dc.identifier.pmid36851045en_US
dc.identifier.scopus2-s2.0-85149203723en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/toxics11020170
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3657
dc.identifier.volume11en_US
dc.identifier.wosWOS:000942030300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofToxicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetamipriden_US
dc.subjectimidaclopriden_US
dc.subjectprobioticen_US
dc.subjectSaccharomyces boulardiien_US
dc.titleReproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Ratsen_US
dc.typeArticleen_US

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