Design, synthesis, antioxidant and anticholinesterase activities of novel isonicotinic hydrazide-hydrazone derivatives

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dc.authoridTOKALI, Feyzi Sinan/0000-0001-5532-8802
dc.contributor.authorAslanhan, Ozlem
dc.contributor.authorKalay, Erbay
dc.contributor.authorTokali, Feyzi Sinan
dc.contributor.authorCan, Zehra
dc.contributor.authorSahin, Engin
dc.date.accessioned2024-10-04T18:49:25Z
dc.date.available2024-10-04T18:49:25Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe design and synthesis of hydrazone derivatives are increasing in popularity day by day due to the significant biological activities of this scaffold. In the present study, twelve novel isonicotinic hydrazide-hydrazone analogues were synthesized by the condensation reaction of isonicotinic hydrazide with ben-zaldehyde possessing sulfonate moiety. The structures of the novel compounds have been characterized in detail using spectroscopic techniques. All compounds have shown inhibitory effects against the AChE en-zyme at rates ranging from 21.00 to 59.48%. Among them, compound 5 has exhibited the best inhibitory effect of 59.48% against AChE at a concentration of 0.1 mM. Furthermore, to determine how effective the novel compounds are as antioxidants, FRAP and DPPH studies were also carried out. FRAP values in compounds 1-12 were found to range from 26.989-3415.556 mu mol FeSO4.7H2O/mg. They also displayed moderate antioxidant potential in the range of SC50= 0.03-87.32 mg/mL compared with the control Trolox (SC50 = 0.004) in DPPH radical scavenging activities. It was seen that the AChE inhibition percentages of the compounds were in the range of 23.04-58.10% at 0.1 mM concentration. This is the first research on the synthesis, antioxidant and enzyme inhibition properties of these compounds. (c) 2023 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.molstruc.2023.135037
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85147089626en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.135037
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3133
dc.identifier.volume1279en_US
dc.identifier.wosWOS:000963608200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydrazide-hydrazoneen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAntioxidant activityen_US
dc.subjectDPPHen_US
dc.subjectFRAPen_US
dc.subjectInhibitionen_US
dc.titleDesign, synthesis, antioxidant and anticholinesterase activities of novel isonicotinic hydrazide-hydrazone derivativesen_US
dc.typeArticleen_US

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