The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results

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dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorMohammadzadeh, Maryam
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.contributor.authorTaspinar, Numan
dc.contributor.authorTogar, Basak
dc.contributor.authorNalci, Kemal Alp
dc.contributor.authorOkkay, Ufuk
dc.date.accessioned2024-10-04T18:53:50Z
dc.date.available2024-10-04T18:53:50Z
dc.date.issued2020
dc.departmentBayburt Üniversitesien_US
dc.description.abstractBackground and Objective: Metformin (MET) has been used as an antidiabetic agent for type II diabetes. At the same time, recent researches have shown that the clinical improvement of MET is useful for nerve damage. In this study, we investigated the analgesic effect of MET in paclitaxel (PAC)-induced neuropathic pain. Materials and Methods: Forty-two adult, female rats, Wistar strain weighing 220 +/- 10 g were randomly divided into 5 experimental groups. PAC was intraperitoneally (IP) administered (2.0 mg/kg) for 4 groups every other day (0, 2, 4, and 6 days). By the 30th day, MET (100, 200, and 400 mg/kg) was administered to 4 groups. Before and after treatment, basal pain threshold values were measured with Randall-Selitto analgesiometer test. At the end of experiment, pathological values were measured in selected regions including brain (motor cortex, M1), spinal cord (L4-L5), sciatic nerve, and muscle. Results: According to our results, PAC-induced neuropathic pain reached to highest level at 14th day. Four hundred milligram/kilogram concentration of MET remarkably decreased PAC-induced neuropathic pain. On the other hand, pathologic features have shown that PAC had significant pathological change in the brain and spinal cord while in the peripheral nerves and muscles had not shown any pathological change. Conclusion: The pathological results of the current study for the first time demonstrated that MET beside of its antidiabetic effects reversed neuropathic pain induced by PAC. Consequently, this research can be promising for cancer patients that suffering from neuropathic pain induced by anticancer drugs.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [113S083]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 113S083).en_US
dc.identifier.doi10.4103/jcrt.JCRT_1455_16
dc.identifier.endpage39en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue1en_US
dc.identifier.pmid32362607en_US
dc.identifier.scopus2-s2.0-85085150552en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_1455_16
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3736
dc.identifier.volume16en_US
dc.identifier.wosWOS:000536629700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetforminen_US
dc.subjectneuropathic painen_US
dc.subjectpaclitaxelen_US
dc.subjectRandall-Selitto analgesiometer testen_US
dc.titleThe analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological resultsen_US
dc.typeArticleen_US

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