Investigation of cytochrome B mutations, and UCP2 and STC1 gene expressions in patients with bipolar disorder

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dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorOzcan, Halil
dc.contributor.authorDirican, Ebubekir
dc.date.accessioned2026-02-28T12:17:58Z
dc.date.available2026-02-28T12:17:58Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractObjective The aim herein was to investigate mitochondrial cytochrome B (MT-CYB) mutations in individuals with bipolar disorder. Stanniocalcin-1 (STC1) and uncoupling protein 2 (UCP2) mRNA expressions and their relationship with clinical data and each other were also investigated. Method The blood samples of 100 individuals were included in this study. Real-time PCR was used to evaluate mRNA expressions of STC1 and UCP2. Genetic alterations were investigated via Sanger DNA sequencing. An in silico analysis was performed to reveal the phenotypic effects of MT-CYB mutations. Results In the MT-CYB gene of the bipolar disorder patients, the most seen mutations were the T194A A>G mutation at position 1532, G deletion at position 15498, and C>A L236I mutation at position 15452. Most of the mutations appeared to be neutral or benign. The UCP2 and STC1 mRNA expression levels were significantly higher in the patients than in the healthy controls (P = 0.0124 and P < 0.0001, respectively). The area under the curve values of the receiver operating characteristic curve analysis for UCP2 and STC1 were 0.6631 (P = 0.0123) and 0.8059 (P < 0.0001), respectively. No significant relationship was observed between the gene expressions and the routine laboratory findings. There was a positive correlation between the UCP2 and STC1 mRNA expressions in the bipolar disorder patients (r = 0.03559, P = 0.0306). Conclusion Expression of UCP2 and STC1 may be important parameters in bipolar disorder. MT-CYB mutations may be related to gene expressions. Comprehensive studies on bipolar disorder will help better understand UCP2 and STC1 gene functions. Psychiatr Genet 35: 58-68 Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved.
dc.identifier.doi10.1097/YPG.0000000000000389
dc.identifier.endpage68
dc.identifier.issn0955-8829
dc.identifier.issn1473-5873
dc.identifier.issue3
dc.identifier.pmid40207595
dc.identifier.scopus2-s2.0-105003082660
dc.identifier.scopusqualityQ3
dc.identifier.startpage58
dc.identifier.urihttps://doi.org/10.1097/YPG.0000000000000389
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6055
dc.identifier.volume35
dc.identifier.wosWOS:001490535500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPsychiatric Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260218
dc.subjectbipolar disorder
dc.subjectmitochondria
dc.subjectmitochondrial cytochrome B
dc.subjectSTC1
dc.subjectUCP2
dc.titleInvestigation of cytochrome B mutations, and UCP2 and STC1 gene expressions in patients with bipolar disorder
dc.typeArticle

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