The wound healing effect and DNA damage repair of exopolysaccharide extracted from Weissella cibaria MED17

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dc.contributor.authorKahraman-Ilikkan, Ozge
dc.contributor.authorDincer, Selin Akad
dc.contributor.authorBagdat, Elif Seyma
dc.contributor.authorCaglar, Isilsu
dc.contributor.authorDertli, Enes
dc.contributor.authorIspirli, Humeyra
dc.contributor.authorSahin, Feride Iffet
dc.date.accessioned2024-10-04T18:54:02Z
dc.date.available2024-10-04T18:54:02Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractLactic acid bacteria can synthesize exopolysaccharides (EPSs), and some of these EPSs have pharmaceutical or medicinal properties. However, the wound healing capacities of EPSs have rarely been reported. In this study, EPS extracted from Weissella cibaria MED17 was used to investigate wound healing capacity. MED17 EPS was previously characterized and antioxidant capacity was also demonstrated. The application dose of the compound was determined by the MTT assay. The comet assay was applied to reveal the free radical scavenging activity and protection capacity of MED 17 against DNA damage by inducing oxidative stress and DNA damage with Mitomycin-C (MMC) in the cells. The comet assay showed that 15 mg/ml MED 17 EPS could ameliorate DNA damage by 50%. Moreover, the scratch test investigated the wound-healing effect of MED 17 EPS on HT-29 colon cells. MED 17 EPS could stimulate the migration of HT-29 and ameliorate MMC-induced DNA damage. However, further studies need to be conducted to clarify the mechanisms of the wound-healing process of MED 17.en_US
dc.description.sponsorshipBaskent University Institutional Review Board [DA 22-25]; Baskent University Research Fund [TSA-2023-5314]; Yimath;ldimath;z Technical University Scientific Research Projects [TSA-2023-5314]en_US
dc.description.sponsorshipThis study was approved by the Baskent University Institutional Review Board (Project no: DA 22-25) and supported by the Baskent University Research Fund and also funded by Y & imath;ld & imath;z Technical University Scientific Research Projects (BAP) with the project number TSA-2023-5314. A part of the manuscript was presented in 11th International Molecular Biology and Biotechnology Congress.en_US
dc.identifier.doi10.1016/j.bcdf.2023.100400
dc.identifier.issn2212-6198
dc.identifier.scopus2-s2.0-85181807183en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.bcdf.2023.100400
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3837
dc.identifier.volume31en_US
dc.identifier.wosWOS:001285783700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBioactive Carbohydrates and Dietary Fibreen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExopolysaccharidesen_US
dc.subjectWound healingen_US
dc.subjectDNA damage repairen_US
dc.subjectWeissella cibariaen_US
dc.titleThe wound healing effect and DNA damage repair of exopolysaccharide extracted from Weissella cibaria MED17en_US
dc.typeArticleen_US

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