Biocatalytic asymmetric synthesis of (S)-1-indanol using Lactobacillus paracasei BD71

Basit Öğe Kaydı
dc.contributor.authorKalay, Erbay
dc.contributor.authorDertli, Enes
dc.contributor.authorSahin, Engin
dc.date.accessioned2024-10-04T18:48:25Z
dc.date.available2024-10-04T18:48:25Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractEnantiopure benzo-fused cyclic alcohols have been used as a building block of a drug for Parkinson's disease. Biocatalytic reduction of ketones is one of the most promising and significant routes to prepare optically active alcohols. In this study, the reductive capacity of seven lactic acid bacteria (LAB) strains were investigated as whole-cell biocatalyst in the enantioselective reduction of 1-indanone (1). Lactobacillus paracasei BD71 was found to have the best reductive capacity. Effects of different parameters such as pH, incubation time, agitation speed and temperature, on enantiomeric excess (ee) and conversion were investigated in a bioconversion. (S)-1-indanol ((S)-2) could be used as precursor for the synthesis of rasagiline mesylate TVP1012 for the therapy of Parkinson's illness. It was produced in gram-scale (5.24 g), high yield (93%) and enantiomerically pure form using L. paracasei BD71 whole-cell biocatalysts. Also, to our knowledge, this is the first report on production of (S)-2 using whole-cell catalyst in enantiopure form, excellent yield, conversion and gram scale. This is a cheap, clean and eco-friendly process for production of (S)-2 compared to chemical processes.en_US
dc.identifier.doi10.1080/10242422.2021.2004133
dc.identifier.endpage392en_US
dc.identifier.issn1024-2422
dc.identifier.issn1029-2446
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85119347087en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.1080/10242422.2021.2004133
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3047
dc.identifier.volume40en_US
dc.identifier.wosWOS:000719228000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiocatalysis and Biotransformationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotransformationen_US
dc.subject(S)-1-indanolen_US
dc.subjectParkinson's drug precursoren_US
dc.subjectwhole-cell biocatalystsen_US
dc.subjectLactobacillus paracasei BD71en_US
dc.titleBiocatalytic asymmetric synthesis of (S)-1-indanol using Lactobacillus paracasei BD71en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu