Highly Enantioselective Production of Chiral Secondary Alcohols Using Lactobacillus paracasei BD101 as a New Whole Cell Biocatalyst and Evaluation of Their Antimicrobial Effects

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorYılmaz, Durmuşhan
dc.contributor.authorŞahin, Engin
dc.contributor.authorDertli, Enes
dc.date.accessioned2020-11-25T19:07:19Z
dc.date.available2020-11-25T19:07:19Z
dc.date.issued20017en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractChiral secondary alcohols are valuable intermediates for many important enantiopure pharmaceuticals and biologically active molecules. In this work, we studied asymmetric reduction of aromatic ketones to produce the corresponding chiral secondary alcohols using lactic acid bacteria (LAB) as new biocatalysts. Seven LAB strains were screened for their ability to reduce acetophenones to their corresponding alcohols. Among these strains, Lactobacillus paracasei BD101 was found to be the most successful at reducing the ketones to the corresponding alcohols. The reaction conditions were further systematically optimized for this strain and high enantioselectivity (99%) and very good yields were obtained. These secondary alcohols were further tested for their antimicrobial activities against important pathogens and significant levels of antimicrobial activities were observed although these activities were altered depending on the secondary alcohols as well as their enantiomeric properties. The current methodology demonstrates a promising and alternative green approach for the synthesis of chiral secondary alcohols of biological importance in a cheap, mild, and environmentally useful process.en_US
dc.identifier.citationYılmaz, D., Şahin, E., & Dertli, E. (2017). Highly enantioselective production of chiral secondary alcohols using Lactobacillus paracasei BD 101 as a new whole cell biocatalyst and evaluation of their antimicrobial effects. Chemistry & biodiversity, 14(11), e1700269.en_US
dc.identifier.doi10.1002/cbdv.201700269
dc.identifier.endpagee1700269en_US
dc.identifier.issue11en_US
dc.identifier.pmid28792667en_US
dc.identifier.scopus2-s2.0-85031725613en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpagee1700269en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2217
dc.identifier.volume14en_US
dc.identifier.wosWOS:000416313000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChemistry Biodiversityen_US
dc.relation.ispartofChemistry Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectBiotransformationen_US
dc.titleHighly Enantioselective Production of Chiral Secondary Alcohols Using Lactobacillus paracasei BD101 as a New Whole Cell Biocatalyst and Evaluation of Their Antimicrobial Effectsen_US
dc.typeArticleen_US

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