A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadine

Basit Öğe Kaydı
dc.authoridKarasu, Cimen/0000-0002-0954-8465
dc.contributor.authorKaya, Alican
dc.contributor.authorCeylan, Asli F.
dc.contributor.authorKavutcu, Mustafa
dc.contributor.authorSantamaria, Abel
dc.contributor.authorPrnova, Marta Soltesova
dc.contributor.authorStefek, Milan
dc.contributor.authorKarasu, Cimen
dc.date.accessioned2024-10-04T18:48:07Z
dc.date.available2024-10-04T18:48:07Z
dc.date.issued2024
dc.departmentBayburt Üniversitesien_US
dc.description.abstractInhibiting aldose reductase (ALR2, AR) as well as maintaining a concomitant antioxidant (AO) activity via dual-acting agents may be a rational approach to prevent cellular glucotoxicity and at least delay the progression of diabetes mellitus (DM). This study was aimed at evaluating the dual-acting AR inhibitor (ARI) cemtirestat (CMTI) on tissue oxidative stress (OS) and carbonyl stress (CS) biomarkers in rats exposed to fructose alone (F) or fructose plus streptozotocin (D; type-2 diabetic). D and F rats were either untreated or treated daily with low- or high-dose CMTI, ARI drug epalrestat (EPA) or antioxidant stobadine (STB) for 14 weeks. Malondialdehyde (MDA), glutathione S-transferase (GST), nitric oxide synthase (NOS), and catalase (CAT) were increased in the sciatic nerve of F and D. These increases were attenuated by low doses of CMTI and STB in D, but exacerbated by low-dose EPA and high-dose CMTI in F. STB and CMTI and to a lesser extent EPA improved MDA, protein-carbonyl, GST and CAT in the hearts and lungs of F and D. CMTI and STB were more effective than EPA in improving the increased MDA and protein-carbonyl levels in the kidneys of F and especially D. CMTI ameliorated renal GST inhibition in D. In the lungs, hearts, and kidneys of F and D, the GSH to GSSG ratio decreased and caspase-3 activity increased, but partially resolved with treatments. In conclusion, CMTI with ARI/AO activity may be advantageous in overcoming OS, CS, and their undesirable consequences, with low dose efficacy and limited toxicity, compared to ARI or antioxidant alone.en_US
dc.description.sponsorshipWe respectfully commemorate Milan Stefek, who passed away while studying on reporting this work.en_US
dc.description.sponsorshipWe respectfully commemorate Milan Stefek, who passed away while studying on reporting this work.en_US
dc.identifier.doi10.1080/01480545.2023.2262164
dc.identifier.endpage720en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue5en_US
dc.identifier.pmid37795621en_US
dc.identifier.scopus2-s2.0-85173789323en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage710en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2023.2262164
dc.identifier.urihttp://hdl.handle.net/20.500.12403/2901
dc.identifier.volume47en_US
dc.identifier.wosWOS:001081316300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectfructoseen_US
dc.subjectaldose reductaseen_US
dc.subjectcemtirestaten_US
dc.subjectepalrestaten_US
dc.titleA dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose- and streptozotocin-induced rats: comparison with antioxidant stobadineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu