Effect of Jackfruıt Pulp Extract on Serum Nesfatın-1 and Vısfatın Levels in Streptozotocın-induced Rats

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dc.contributor.authorErkilic, T. Orkun
dc.contributor.authorBayraktar, B.
dc.date.accessioned2026-02-28T12:18:10Z
dc.date.available2026-02-28T12:18:10Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: The aim of this study was to investigate the effects of different amounts of jackfruit pulp extract (JPE) in the diets on serum nesfatin-1 and visfatin levels in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were created, with 8 rats in each group: Control (C), J100 (JPE 100 mg/kg group given with oral gavage route of administration (OGRA), J200 (JPE 200 mg/kg group given with OGRA), J300 (JPE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, DJ100 (D+100 mg/kg JPE), DJ200 (D + 200 mg/kg JPE), DJ300 (D). + 300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (Vena caudalis) of all subjects on days 0 and 21 of the study. Nesfatin-1 and visfatin levels in the serum samples were measured by ELISA method. Result: As a result, in the diabetes groups of our study, the most significant increase in the mean serum nesfatin-1 level and the most significant decrease in the mean serum visfatin level occurred in the DJ200 groups at the end of the 21st day due to the addition of JPE (p<0.05). As a result, it was concluded that JPE may be safe and beneficial when administered at a dose of 200 mg/kg in diabetic groups.
dc.identifier.doi10.18805/IJAR.BF-1902
dc.identifier.endpage298
dc.identifier.issn0367-6722
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85218246717
dc.identifier.scopusqualityQ3
dc.identifier.startpage293
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1902
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6141
dc.identifier.volume59
dc.identifier.wosWOS:001454903900017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectJackfruit
dc.subjectNesfatin-1
dc.subjectRat
dc.subjectType 1 diabetes mellitus
dc.subjectVisfatin.
dc.titleEffect of Jackfruıt Pulp Extract on Serum Nesfatın-1 and Vısfatın Levels in Streptozotocın-induced Rats
dc.typeArticle

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