Association of Plasma miRNA-7-5p and miRNA-214-5p With Rheumatoid Arthritis Associated Interstitial Lung Disease

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dc.contributor.authorSahinoglu, Irem
dc.contributor.authorKarakas, Umit
dc.contributor.authorUslu, Sadettin
dc.contributor.authorKizilirmak, Deniz
dc.contributor.authorAcar, Emre Ali
dc.contributor.authorTasgoz, Filiz Cemre
dc.contributor.authorGunduz, Ozgul Soysal
dc.date.accessioned2026-09-01T15:52:36Z
dc.date.available2026-09-01T15:52:36Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractObjective Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a major extra-articular complication contributing to increased morbidity and mortality. Circulating microRNAs (miRNAs) have emerged as potential non-invasive biomarkers in autoimmune diseases. This study aimed to evaluate whether plasma miRNA-7-5p and miRNA-214-5p are associated with the presence of RA-ILD and with radiological and functional indicators of pulmonary involvement. Methods In this cross-sectional study, 58 RA patients (29 RA-ILD, 29 without ILD) and 30 matched healthy controls were included. RA-ILD was diagnosed by multidisciplinary assessment (HRCT and pulmonary function tests). Plasma miRNA levels were measured by qRT-PCR and analyzed using the 2<^>-Delta Delta CT method. Diagnostic performance was evaluated by ROC analysis. Results Plasma miRNA-7-5p and miRNA-214-5p levels were significantly higher in RA patients compared with healthy controls (p < 0.05 for both). Among RA patients, both miRNAs were significantly lower in those with ILD (p < 0.05). miRNA-7-5p demonstrated promising discriminatory performance for identifying RA-ILD (AUC = 0.87, 95% CI: 0.760-0.947; p < 0.001), whereas miRNA-214-5p showed modest accuracy (AUC = 0.676, 95% CI: 0.539-0.794; p = 0.01). In multivariable analysis, ILD presence was independently associated with decreased levels of both miRNAs. Neither miRNA correlated significantly with DAS28-CRP, disease duration, nor with radiological or functional severity parameters. Conclusion Circulating miRNA-7-5p and miRNA-214-5p are associated with the presence of RA-ILD but do not reflect disease severity in this cohort. Larger prospective studies are required to validate their potential role as adjunctive biomarkers for RA-ILD detection and risk stratification.
dc.description.sponsorshipManisa Celal Bayar University Scientific Research Projects Coordination Unit [2024-037] -- This study was supported by the Manisa Celal Bayar University Scientific Research Projects Coordination Unit, Project Number: 2024-037.
dc.identifier.doi10.1111/1756-185x.70820
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue8
dc.identifier.pmid42572845
dc.identifier.scopus2-s2.0-105046781690
dc.identifier.scopusqualityQ3
dc.identifier.urihttp://dx.doi.org/10.1111/1756-185x.70820
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8493
dc.identifier.volume29
dc.identifier.wosWOS:001844525900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260820
dc.subjectBiomarkers
dc.subjectInterstitial Lung Disease
dc.subjectMicrornas
dc.subjectRheumatoid Arthritis
dc.titleAssociation of Plasma miRNA-7-5p and miRNA-214-5p With Rheumatoid Arthritis Associated Interstitial Lung Disease
dc.typeArticle

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